Antibacterial Activity of Quaternary Ammonium Antibacterial Compounds with Different Chain Lengths
Bacterial infection is a serious threat to human health.To develop new antibacterial molecules,three quaternary ammonium antibacterial compounds were synthesized using three long chain tertiary amine compounds and 4-(bromomethyl)phenylboric acid as raw materials.The introduction of phenylboronic acid aimed to enhance the adhesion of quaternary ammonium antibacterial compounds to bacterial cell walls and therefore enhance their antibacterial activity.Then the antibacterial activity of the three phenylboronic acid-containing ammonium compounds against Escherichia coli(Gram-negative bacteria),Staphylococcus aureus(Gram-positive bacteria)and methicillin-resistant Staphylococcus aureus(MRSA,drug-resistant bacteria)was evaluated by real-time killing curve,minimum inhibitory concentration,and plate coating method,respectively.Our results revealed that the three phenylboronic acid-containing ammonium antibacterial compounds could significantly inhibit the growth of Escherichia coli,Staphylococcus aureus and MRSA,showed excellent antibacterial activity against the three bacteria,and the antibacterial activities increased with the increasing of chain length.
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