首页|药材粒度对冷浸法提取水冬瓜伤科止痛酊中黄芩苷和总固体物收率的影响

药材粒度对冷浸法提取水冬瓜伤科止痛酊中黄芩苷和总固体物收率的影响

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目的:考察不同药材粒度(最粗粉、粗粉、中粉、细粉)对冷浸法提取水冬瓜伤科止痛酊中黄芩苷和总固体物收率的影响.方法:采用高效液相色谱法测定黄芩苷,采用干燥失重法测定总固体物收率.以黄芩苷含量和总固体物收率为指标,优选制备水冬瓜伤科止痛酊最适宜的药材粒度.结果:最粗粉制得的酊剂中黄芩苷含量和总固体物收率均最高,分别是416.1 μg/mL、18.08%.结论:药材粉碎粒度对黄芩苷含量和总固体物收率均有影响.
Effect of particle size on baicalin content and total solid yield of Shuidonggua Painkilling Tincture prepared by cold soak
We studied the effect of different particle sizes(the coarsest,coarse,medium and fine)on the baicalin content and total solid yield of Shuidonggua Painkilling Tincture extracted by cold soak.Baicalin was determined by high performance liquid chromatography,and the total solid yield was measured by loss on drying method.The ba-icalin content and total solid yield were taken as indicators to optimize the particle size for the preparation of Shui-donggua Painkilling Tincture.The results showed that the baicalin content and total solid yield of the tincture pre-pared from the coarsest powder were the highest,reaching 416.1 μg/mL and 18.08%,respectively.Different parti-cle sizes have different effect on the baicalin content and total solid yield of Shuidonggua Painkilling Tincture.

Shuidonggua Painkilling Tincturedifferent particle sizesbaicalintotal solid yield

杨元凤、罗玉玲、代欣、陈永敏、周训蓉

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贵州中医药大学第二附属医院 药学部,贵州 贵阳 550003

贵州中医药大学 中药制剂研发中心,贵州 贵阳 550003

贵州中医药大学 制剂研究中心,贵州 贵阳 550003

水冬瓜伤科止痛酊 不同粉碎粒度 黄芩苷 总固体物收率

贵州省中医药管理局中医药、民族医药科学技术课题研究资助项目贵州中医药大学院内科研项目

QZYY2013-743040-04020001406

2024

贵州科学
贵州科学院

贵州科学

影响因子:0.395
ISSN:1003-6563
年,卷(期):2024.42(1)
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