Screening of the best active part of Lespedeza buergeri Miq.for the treatment of traumatic chronic wounds and analysis of its components
We studied the effect of different polar parts of Lespedeza buergeri Miq.in promoting the healing of trau-matic chronic wounds,and selected the best active part to study its composition.Chronic traumatic wounds were es-tablished and Lespedeza buergeri extracts of different polarities were given to screen the best active part by the degree of wound healing.The best active part was analyzed by LC-MS full spectrum analysis.The results showed that the extracts of different polar parts of Lespedeza buergeri had different degree of therapeutic effect on traumatic chronic wounds,among which the petroleum ether extract had the best therapeutic effect.The results of LC-MS full spec-trum analysis showed that the petroleum ether extract contained large amounts of fatty acyl,flavonoids and isofla-vonoids,carboxylic acids and their derivatives,coumarins and their derivatives,etc.In conclusion,the petroleum e-ther extract of Lespedeza buergeri was most effective in the treatment of chronic traumatic wounds in rats,probably as a result of the synergistic effect of fatty acyl,flavonoids,coumarins and carboxylic acid compounds.
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