Action mechanism of Dendrobium nobile Lindl.alkaloids against after-cataract based on network pharmacology and molecular docking
This paper investigates the action mechanism of Dendrobium nobile Lindl.alkaloids against after-cata-ract.The active components of Dendrobium nobile Lindl.alkaloids and their structures are collected by reviewing do-mestic and foreign literature.Network pharmacology is used to predict the potential targets of Dendrobium nobile Lindl.alkaloids against after-cataract,the protein interaction network(PPI)is established,and GO analysis and KEGG pathway enrichment analysis are conducted to explore the possible biological processes and pathways of Den-drobium nobile Lindl.alkaloids against after-cataract.The binding activity of Dendrobium nobile Lindl.alkaloids to the core targets is verified by molecular docking.27 active ingredients of Dendrobium nobile Lindl.alkaloids are ob-tained,and the core targets of Dendrobium nobile Lindl.alkaloids against after-cataract are STAT3,PIK3R1,AKT1,etc.The GO enrichment analysis results indicate that Dendrobium nobile Lindl.alkaloids mainly exert enzyme bind-ing and protein binding through affecting biological processes such as apoptosis,cell migration and bidirectional reg-ulation of kinase activity,etc.The effect of Dendrobium nobile Lindl.alkaloids against after-cataract may be related to signaling pathways such as angiogenesis(HIF-1 signaling pathway)and inflammatory response(PI3K-Akt sig-naling pathway).The molecular docking results show that Dendrobium nobile Lindl.alkaloids have good binding ac-tivity to all core targets.In conclusion,dendrobine and N-trans-feruloyl tyramine in Dendrobium nobile Lindl.may exert their effect against after-cataract through STAT3,PIK3R1,AKT1 and other targets and signaling pathways.This study has provided theoretical guidance for future validation and development of Dendrobium nobile medicines.
NETL
NSTL
万方数据
维普
