Action mechanism of tonic anti-TB granules in the treatment of pulmonary tu-berculosis based on network pharmacology
This paper explores the action mechanism of tonic anti-TB granules in the treatment of pulmonary tu-berculosis based on network pharmacology.The main chemical components of tonic anti-TB granules are collected in TCMSP database,the active ingredients are screened out based on drug distribution,absorption,metabolism and excretion(ADME),and the corresponding targets are obtained.The important targets of pulmonary tuberculosis(PTB)are obtained in Drugbank,Genecards and OMIM databases,and the duplicate values are removed.Protein interaction analysis is performed using String database,and the PPI network is constructed.The drug-disease targets-pathway network is constructed by using Cytoscape 3.7.1,and the top-ranked core targets are screened out.GO function and KEGG signaling pathway enrichment analysis are performed on the targets in the PPI network by using Microbiology database.232 drug targets and 1452 non-duplicated disease targets are screened out,and 110 intersec-ted targets are obtained.The top five core targets are quercetin,kaempferol,luteolin,isorhamnetin,and hederagenin.PPI analysis show that RELA,TP53,TNF,AKT1 and IL-6 are the core gene targets.In conclusion,tonic anti-TB granules exert the therapeutic effect on pulmonary tuberculosis through multi-targets and multi-pathways.
NETL
NSTL
万方数据
维普
