Action mechanism of antibacterial efficacy of volatile oil of Cinnamomum migao based on network pharmacology and molecular docking
In this study we investigated the main active ingredients and potential action mechanism of the volatile oil of Cinnamomum migao based on network pharmacology and molecular docking.The chemical composition of the volatile oil of Cinnamomum migao was searched through TCMSP,CNKI and other databases,and the targets related to the antibacterial efficacy were predicted.The active ingredient-target network was constructed.The intersecting targets were used for GO and KEGG enrichment analysis and molecular docking to predict the binding of the active ingredients to the key targets.A total of 9 volatile oil components,151 related targets and 54 common antibacterial targets were obtained,which were involved in cancer pathway,IL-17 signaling pathway and other signaling path-ways.Molecular docking results showed that the core component 7,8-epoxy-α-viologenone had high binding activi-ty with PTGS2,Thymol and ALB.In conclusion,the volatile oil of Cinnamomum migao may bind to the targets through 7,8-epoxy-α-viologenone,thymol and other components,and participate in cancer,inflammation and other related signaling pathways to play an antibacterial role.
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