Study on extraction and purification technology of Qijin Granules
We optimized the extraction and purification process of Qijin Granules.The extraction technology of Qi-jin Granules was comprehensively evaluated by single factor tests and L9(34)orthogonal test with the extraction rate and morroniside content as evaluation indexes.The clarification process with ethanol as solvent was formulated ac-cording to the physicochemical properties of each active component in the prescription,and the optimal extraction and purification conditions were determined.The optimal extraction and purification conditions were as follows;8 times the amount of water;decocting and extracting 3 times,0.5 h each time;concentrating the combined extraction solution to the concentrated solution with a relative density of 1.23 to 1.28;adding 95％ethanol slowly while stir-ring,until the alcohol concentration reached 80;standing still overnight,filtrating and recovering the ethanol.The extraction rate was 19.5％,and the extraction rate of morroniside was 93.50％.The active ingredients of the prep-aration were retained to the maximum extent.The extraction method is feasible,has high retention rate of the effec-tive components and good effect of impurity removal,and is suitable for the extraction and purification process of Qi-jin Granules.
万方数据
维普
