Action mechanism of modified Xiaoluo Pills in the treatment of pulmonary nodu-lar disease based on network pharmacology
This paper explores the action mechanism of modified Xiaoluo Pills in the treatment of pulmonary nod-ular disease based on network pharmacology.The main chemical constituents and the corresponding targets of modi-fied Xiaoluo Pills were obtained from TCMSP database,and the targets and gene names were converted by using UniProt database.The targets of pulmonary nodular disease were retrieved and deduplicated in OMIM and Gene-Cards databases.The intersection of targets was mapped by using Venny 2.1.0 online tool.Cytoscape(v3.9.1)software was used to draw the drug-chemical component-target network diagram to screen the key components that play a therapeutic role.Using the STRING platform,the intersection target interactions of the drug and the disease was carried out,and the PPI network was constructed.Cytoscape(v3.9.1)was used to process the PPI network to obtain the key targets of modified Xiaoluo Pills in the treatment of pulmonary nodular disease.GO and KEGG en-richment analysis of the intersecting targets were carried out to find out the potential action mechanism.After screening,42 active ingredients and 225 corresponding targets of modified Xiaoluo Pills,and 1530 therapeutic tar-gets of pulmonary nodular disease were obtained.After target mapping,16 potential targets of modified Xiaoluo Pills in the treatment of pulmonary nodular disease were obtained;the key ingredients included quercetin,β-sitosterol,kaempferol,naringenin,stigmasterol and isorhamnetin,the key targets included TP53,AKT1,RELA,MAPK3,MAPK1,TNF and IL6,and the key pathways included TNF signaling pathway,IL-17 signaling pathway,lipid and atherosclerosis pathway.In conclusion,modified Xiaoluo Pills exerts its therapeutic effect on pulmonary nodular dis-ease through multi-components,multi-targets,and multi-pathways.
NETL
NSTL
万方数据
