首页|益肾结透合剂制备工艺研究和验证

益肾结透合剂制备工艺研究和验证

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目的:优选益肾结透合剂的制备工艺,并验证制备工艺的可行性.方法:以绿原酸含量为指标,固液比、煎煮时间、煎煮次数为考察因素,采用L9(34)正交试验优选益肾结透合剂提取工艺;并通过验证试验验证工艺条件的可靠性.结果:采用水煎煮提取,浸泡0.5 h,固液比1∶10,水提取2 次,1h/次.滤液合并,常压浓缩至约800 mL,加辅料羟苯乙酯0.5 g,精滤,加纯化水至1000 mL,混匀,即得.结论:该制备工艺可行、合理,可作为益肾结透合剂的制备工艺.
Study and verification of the preparation technology of Yishen Jietou Mixture
In this study we optimized the preparation technology of Yishen Jietou Mixture and verified its feasibili-ty.With the chlorogenic acid content as the index,and the solid-liquid ratio,decocting time and decocting times as the factors,the L9(34)orthogonal test was used to optimize the extraction process.The reliability of the process con-ditions was verified by verification tests.The optimum preparation technology was as follows:steeping for 0.5 hour with a solid-liquid ratio of 1∶10,extracting twice with water for 1 hour each time,mixing the filtrates,concentra-ting under atmospheric pressure to about 800 mL,adding 0.5 g ethylparaben,performing refined filtration,and adding purified water to 1000 mL.The preparation process is feasible and reasonable,and can be used as the prepa-ration process of Yishen Jietou Mixture.

Yishen Jietou Mixturepreparation technology studyorthogonal experimentverification test

任龙艳、杨亮、曾真、蒋玲、梁会、王霞

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贵州中医药大学,贵州 贵阳 550025

贵州中医药大学第二附属医院,贵州 贵阳 550001

益肾结透合剂 制备工艺研究 正交实验 验证试验

2024

贵州科学
贵州科学院

贵州科学

影响因子:0.395
ISSN:1003-6563
年,卷(期):2024.42(6)