In order to selected a suitable origin processing method, taking the contents of polysaccharide, lobetyolin, ethanol-soluble extraction and water-soluble extraction as the indexes, comprehensive score method was used to study the processing method of Codonopsis.Results:Cleaning, infiltrating, drying, sweating and kneading all have significant effects on the main chemical constituents of Codonopsis.The optimal conditions are as follows, one time water grab cleaning, infiltrating with 1% dosage of the aluminum infiltration in five minutes, drying in the shade, sweating with weight loss rate 60% and sweating for three days, kneading 1 times,and the comperhensive score was 0.797,0.522,0.700,0.692 and 0.601 respectively.