Alleviative Effects of Plant Extract A on Menopausal Syndrome in SD Rats
The regulatory effects of plant extract A on menopausal syndrome,particularly osteoporosis,was investigated.A menopausal rat model was established through ovariectomy,followed by continuous gavage for 14 weeks.Five groups,comprising blank group,control group,and low-,medium-,and high-dose groups,were designated.The results revealed that plant extract A improved the uterine condition of menopausal rats by regulating the secretion of sex hormones,leading to increased serum estradiol(33.33%)and serum anti-Müllerian hormone(134.78%)levels,and decreased serum follicle stimulating hormone(8.42%)levels.Additionally,plant extract A enhanced the structures and functions of bone tissues in menopausal rats.It also increased total bone mineral density(8.00%),distal bone mineral density(7.69%),and midshaft bone mineral density(8.33%),as well as the levels of blood phosphorus(14.04%),calcium(12.58%),bone calcium(34.87%)and serum 25-hydroxy vitamin D(78.40%)levels,fibroblast growth factor(60.21%),procollagen I N-terminal pro-peptide(128.57%),alkaline phosphatase(40.00%),and osteocalcin(51.61%)in menopausal rats.However,it reduced the level of C-terminal telopeptide of type I procollagen(34.22%).In conclusion,plant extract A can effectively regulate the secretion of sex hormones in menopausal rats and alleviate osteoporosis symptoms.This study offers valuable insights into the potential promotion and application of plant extract A as a functional food to mitigate menopausal syndrome symptoms.
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