摘要
该文研究了植物提取物A对更年期综合征尤其是骨质疏松的调节功效.采用卵巢摘除手术建立更年期大鼠模型,设置空白组、模型组、低、中、高剂量组五组,连续灌胃14周.结果表明,植物提取物A可改善更年期大鼠子宫状态,还可调节更年期大鼠性激素分泌,提高血清中雌二醇含量(33.33%),降低血清促卵泡激素分泌(8.42%),促进抗苗勒氏管激素分泌(134.78%).并且植物提取物A可改善更年期大鼠的骨组织结构和功能,提高更年期大鼠的血磷(14.04%)、血钙(12.58%)含量;提高更年期大鼠的全骨骨密度(8.00%)、骨远端骨密度(7.69%)、骨中段骨密度(8.33%)以及骨钙含量(34.87%);提高更年期大鼠血清25羟维生素D(Serum 25-hydroxy Vitamin D)水平(78.40%),升高成纤维生长因子水平(60.21%)调节机体代谢,提高碱性磷酸酶(40.00%)、骨钙素含量(51.61%),降低I型前胶原交联C末端肽含量(34.22%),提高I型前胶原N端肽含量(128.57%),对缓解骨质疏松有显著功效.该研究可为植物提取物A作为缓解更年期综合征的功能食品推广应用提供参考依据.
Abstract
The regulatory effects of plant extract A on menopausal syndrome,particularly osteoporosis,was investigated.A menopausal rat model was established through ovariectomy,followed by continuous gavage for 14 weeks.Five groups,comprising blank group,control group,and low-,medium-,and high-dose groups,were designated.The results revealed that plant extract A improved the uterine condition of menopausal rats by regulating the secretion of sex hormones,leading to increased serum estradiol(33.33%)and serum anti-Müllerian hormone(134.78%)levels,and decreased serum follicle stimulating hormone(8.42%)levels.Additionally,plant extract A enhanced the structures and functions of bone tissues in menopausal rats.It also increased total bone mineral density(8.00%),distal bone mineral density(7.69%),and midshaft bone mineral density(8.33%),as well as the levels of blood phosphorus(14.04%),calcium(12.58%),bone calcium(34.87%)and serum 25-hydroxy vitamin D(78.40%)levels,fibroblast growth factor(60.21%),procollagen I N-terminal pro-peptide(128.57%),alkaline phosphatase(40.00%),and osteocalcin(51.61%)in menopausal rats.However,it reduced the level of C-terminal telopeptide of type I procollagen(34.22%).In conclusion,plant extract A can effectively regulate the secretion of sex hormones in menopausal rats and alleviate osteoporosis symptoms.This study offers valuable insights into the potential promotion and application of plant extract A as a functional food to mitigate menopausal syndrome symptoms.
维普
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