Effects of Angelica sinensis Volatile Oil on Depressive Behavior in Mice
To determine the effects and mechanism of Angelica sinensis volatile oil(ASVO)on depressive behavior,chronic unpredictable mild stress(CUMS)-induced depression mouse models were established.Mice were divided into normal,model,low-dose,medium-dose,and high-dose ASVO(15,30,and 60 mg/kg,respectively),and fluoxetine hydrochloride(2.1 mg/kg)groups.After four weeks of intervention,the number of central zone crossing,central zone activity duration,and sucrose preference were increased(P<0.01)while the tail suspension time was reduced(P<0.05,P<0.01)in all ASVO groups compared with those in the model group.The pathological changes in the hippocampal CA1 region were alleviated,and the contents of serum interleukin-1β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α)decreased(P<0.01)while that of IL-10 increased(P<0.01).Despite no significant changes in the dopamine(DA)content and neurotrophin-3(NT-3)expression in the brain tissue of mice in the low-dose ASVO group(P>0.05),the contents of DA,norepinephrine(NE),and 5-hydroxytryptamine(5-HT)and the expression of nerve growth factor(NGF),NT-3,and brain-derived neurotrophic factor(BDNF)increased in the other groups(P<0.05,P<0.01).These results indicate that ASVO can improve CUMS-induced depressive behavior in mice,which is related to the inhibition of neuroinflammation,upregulation of monoamine neurotransmitter contents,and promotion of neurotrophic factor expression.
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维普
