The in vitro antioxidant activity of fermented qushi decoction(FQD)was evaluated based on the free radical scavenging capacity.The results showed that the total antioxidant capacity of the high-dose FQD group was significantly higher than that of the unfermented qushi decoction(QD)group.In particular,the 2,2-diphenyl-1-picrylhydrazyl(DPPH)and hydroxyl radical scavenging rates and the total antioxidant capacity significantly increased by 24.38%,11.98%,and 11.76%,respectively,in the high-dose FQD group.FQD showed no significant effects on the total egg production of Caenorhabditis elegans.However,the average lifespan of C.elegans increased by 8.02%to 26.36%after FQD intervention.Under heat stress and oxidative stress conditions,the maximum survival time of C.elegans was extended by 25%and 16.67%in the FQD groups,,respectively.In addition,the antioxidant enzyme activity of C.elegans was significantly enhanced(P<0.05)and the level of lipofuscin accumulation was reduced after FQD intervention.In conclusion,FQD provides anti-aging effects on C.elegans by increasing the in vitro antioxidant capacity,prolonging the lifespan of C.elegans,enhancing stress resistance,and improving the antioxidant enzyme activity.This study tentatively indicates that FQD has anti-aging effects,and the findings provide a theoretical basis for the development and utilization of related nutraceuticals.
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