首页|白番茄提取物组合物抗糖化及抗小鼠衰老作用评价

白番茄提取物组合物抗糖化及抗小鼠衰老作用评价

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该研究通过建立体外抗糖化模型、抗氧化模型及小鼠衰老模型,评价白番茄组合物抗糖化、抗氧化及抗小鼠衰老的效果.实验结果表明,在质量浓度为0.2 mg/mL时,组合物对果糖胺、活性羰基化合物和荧光性晚期糖基化终末产物抑制率分别为44.39%、19.22%和69.28%,组合物抗糖基化效果优于氨基胍.组合物对O2-·、羟基和ABTS+自由基均有显著的清除作用,组合物的清除自由基能力:ABTS+·>·OH>O2-·.细胞实验表明,组合物可显著减轻丙酮醛的细胞毒性,提高HepG2细胞活力(P<0.05).在小鼠衰老模型中,组合物可改善D-半乳糖诱导的肝损伤并显著恢复肝脏总超氧化物歧化酶水平(P<0.05).由此可知,这款含白番茄提取物组合物具有较好的抗糖基化、抗氧化能力和抗衰老能力,将在功能食品、保健品行业有较好的应用前景.
Anti-glycation Effects of Lumenato Extract Complex and Its Anti-aging Effects in Mice
The anti-glycation,antioxidant,and anti-aging effects of Lumenato extract complex were examined by establishing in vitro anti-glycation and antioxidant models and an in vivo model of aging in mice,respectively.The results revealed that the application of the extract complex at a concentration of 0.2 mg/mL resulted in inhibition rates of 44.39%,19.22%,and 69.28%were for fructosamine,active carbonyl compounds,and fluorescent advanced glycation end-products,respectively.Furthermore,the anti-glycation effects of the complex were found to be superior to those of aminoguanidine,and the complex exhibited significant scavenging effects on O2-·,OH,and ABTS+·(in the order ABTS+·>·OH>O2-·).In addition,cell experiments revealed that the complex can significantly reduce the cytotoxicity of methylglyoxal and enhance the viability of HepG2 cells(P<0.05).In the mouse aging model,the complex alleviated the liver injury induced by D-galactose,as well as restored liver total superoxide dismutase levels(P<0.05).These findings thus provide evidence indicating that with respect to its anti-glycation,antioxidant,and anti-aging properties,Lumenato extract complex has promising application potential in the functional food and health product industries.

advanced glycation end-productLumenato extractanti-glycationanti-aging

刘会平、刘弘基、李少飞、陈晓、蒋亮、冯东亮、罗振铧、罗洁玲、廖文镇

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时代生物科技(深圳)有限公司,广东 深圳 518115

南方医科大学公共卫生学院营养与食品卫生学系,广东 广州 510515

晚期糖基化终末产物 白番茄提取物 抗糖化 抗衰老

2024

现代食品科技
华南理工大学

现代食品科技

CSTPCD北大核心
影响因子:1.07
ISSN:1673-9078
年,卷(期):2024.40(11)