The large-scale official mining of lead and zinc mines in the early Qing Dynasty had a profound impact on the politics, economy, and culture of northwest Guizhou. This article takes Shuicheng, which is rich in lead and zinc resources, as a representative of it. From the establishment of Shuicheng Hall and the position of lead and zinc mines in the Qing court's coinage and firearms manufacturing industry, the article focuses on the development process of Shuicheng lead and zinc mines represented by Fuji Factory and Monkey Factory.According to some scholar's researches, which have some surveys on the mining , smelting, or transportation of the mine industry, and providing a reference for scholars to deeply study the history of Shuicheng mining.