目的:评价非药物康复干预措施对乳腺癌患者化疗相关认知障碍的治疗效果.方法:检索Pubmed,Cochrane library,Embase,Web of science,中国知网,万方,维普,CBM数据库符合研究目的的随机对照试验,检索时限截止到2022年2月,应用Stata 16.0软件进行网状Meta分析.结果:纳入研究22项,共10种非药物干预方法,并且纳入的研究均未报告显著不良事件,表明这10种非药物干预措施对于治疗化疗相关认知障碍是安全的.网状结果显示,相比于常规护理,最有效的干预措施排序为正念疗法、认知训练.结论:非药物康复干预对乳腺癌化疗相关认知障碍的治疗安全有效,其中正念疗法和认知训练的干预效果可能最佳,这一结果为临床决策提供了循证数据支持,未来需进行更多高质量研究探索最佳性价比的干预措施.
Non-pharmacological interventions for chemotherapy-related cognitive impairment in breast cancer patients:a network meta-analysis
Objective:To assess the effectiveness of non-pharmacological interventions on chemotherapy-related cognitive impairment in breast cancer patients.Methods:Pubmed,Cochrane library,Embase,Web of science,CNKI,Wanfang,VIP,and CBM database were searched for randomized controlled trials that meet the research purpose,which was conducted from the inception of database to February 2022,and network meta-analysis was performed by Stata 16.0 software.Results:Twenty-two studies were included,involving 10 non-pharmacological interventions,and none of the included studies reported significant adverse events,indicating that these 10 non-pharmacological interventions are safe for the treatment of chemotherapy-related cognitive impairment.The network results showed that,compared with usual care,the most effective interventions were mindfulness therapy and cognitive training.Conclusions:Non-pharmacological interventions are safe and effective for the treatment of breast cancer chemotherapy-related cognitive impairment,among which mindfulness therapy and cognitive training may have the best effect.This result provides evidence-based data support for clinical decision-making,more high-quality studies should be required to get interventions with the best cost performance explored in the future.
NETL
NSTL
万方数据
