Application of dexmedetomidine combined with spinal epidural anesthesia in cesarean section of preeclampsia parturients
Objective:To investigate the effect of dexmedetomidine combined with spinal epidural anesthesia in cesarean section of preeclampsia parturients.Methods:A total of 78 pregnant women with preeclampsia who underwent cesarean section in our hospital from December 2019 to December 2022 were collected and randomly divided into observation group and control group,with 39 cases in each group.Both groups were given combined spinal-epidural anesthesia.The observation group was infused with dexmedetomidine after delivery of the fetus,and the control group was given the same amount of normal saline.The anesthesia quality,and sedation Ramsay score,hemodynamic indexes,stress response indexes at different time point were compared between the two groups.Results:There was no significant difference in the onset time of nerve block,the onset time of motor block and the time to reach the highest anesthesia plane between the two groups(all P>0.05).At 10 min,20 min after anesthesia and 24 h after operation,the Ramsay scores of sedation in the observation group were significantly higher than those in the control group(all P<0.05).There was no significant difference in mean arterial pressure(MAP)between the two groups at each time point(all P>0.05).There was no significant difference in heart rate(HR)between the two groups before anesthesia(P>0.05).The HR of the observation group were lower than those of the control group at 10 min after delivery and 24 h after operation(both P<0.05).The levels of serum cortisol(Cor),superoxide dismutase(SOD)and malondialdehyde(MDA)in the two groups at 1 h after operation were higher than those before anesthesia(all P<0.05).At 1 h after operation,the levels of serum Cor and MDA in the observation group were lower than those in the control group,while the level of SOD was higher than that in the control group(all P<0.05).Conclusion:Dexmedetomidine combined with spinal-epidural anesthesia for preeclampsia parturients undergoing cesarean section can improve the effect of anesthesia and sedation,maintain hemodynamic stability,reduce stress response,and help parturients pass the perinatal period smoothly.
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