Bioinformatics-based analysis of MBD1 expression and clinical significance in Liver Hepatocellular Carcinoma
Objective:To analyze the expression and clinical significance of MBD1 in Liver Hepatocellular Carcinoma(LIHC)based on bioinformatics online databases.Methods:TIMER2.0,UALCAN,HPA and LinkedOmics databases were used to analyze the expression level of MBD1 gene in LIHC and normal liver tissues and its relationship with patient prognosis,co-expressed genes were analysed and enrichment analysis of KEGG signaling pathways was also performed.Results:The expression of MBD1 in LIHC tissues(371 cases)was higher than that in normal tissues(50 cases);the expression of MBD1 increased with the increase of clinical stage;moreover,the expression level of MBD1 was higher in TP53 mutations(P<0.05).Survival analysis showed that the survival probability of LIHC patients with high expression of MBD1 were significantly poor(P<0.05).Co-expression analysis showed that a total of 6196 genes were significantly and positively correlated with MBD1 expression(P<0.05),and the gene with the highest positive correlation expression was PIAS2,with a correlation coefficient of 0.589;1946 genes were significantly and negatively correlated with MBD1 expression(P<0.05),with HEBP2 having the highest negative correlation expression,with a correlation coefficient of-0.328.KEGG results showed that MBD1 may be related to cell cycle,ubiquitin mediated proteolysis,RNA transport,viral carcinogenesis,and other signaling pathways.Conclusion:The expression level of MBD1 in LIHC tissues is increased,and the prognosis of LIHC patients with high expression of MBD1 is poor,which may become a new therapeutic target for LIHC.
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