A calinical study on the short-term efficacy of 32P brachytherapy combined with triamcinolone acetonide sequential therapy for skin keloids and VTIQ evaluation application
Objective:To assess the short-term efficacy of 32P brachytherapy combined with intralesional triamcinolone acetonide mixture injection in the treatment of skin keloids and the preliminary application value of virtual touch tissue imaging quantification(VTIQ).Methods:A total of 34 lesions in 23 patients with skin keloids who attended our Nuclear Medicine Clinic from June 2022 to 2023 January were treated with 32P brachytherapy+intralesional triamcinolone acetonide mixture injection as observation group,while 42 lesions in 29 patients of control group treated with only 32P brachytherapy from June 2020 to 2023 January.The modified Vancouver Score Scale(VSS)was performed before and after treatment.The shear wave velocity(SWV,m/s)was measured by the VTIQ to assess the short-term efficacy.Results:(1)102 times of intralesional triamcinolone acetonide mixture injections and 68 times of 32P application brachytherapy were completed in experimental group,and 173 times of 32P application in control group.The total short-term effective rates(effective and cured)were 79.41％and 80.95％(x2=0.028,P=0.867)in observation group and control group respectively.The times and duration of treatment in the experimental group were significantly less than those of the control group[2.00(2.00,2.00)vs 4.00(3.25,5.00),66.00(63.25,72.00)vs 169.0(132.2,194.0),P<0.01).(2)In observation group,the SWVmax(m/s)and SWVmean(m/s)after treatment were significantly lower than those of before treatment(5.79±3.05 vs 6.75±3.80,4.68±1.92 vs 5.35±2.38,P<0.05),the modified VSS score after treatment was lower than before(9.04±1.85 vs 11.03±2.33,P<0.01),there was a certain correlation between SWVmean and the modified VSS score before treatment(r=0.44,P<0.05).Conclusion:The short-term effect of sequential treatment in skin keloids with 32P brachytherapy combined with intralesional injection of triamcinolone acetonide mixture is satisfactory.Compared with 32P application alone,it significantly reduced the times of treatments and shortened duration without reducing the efficacy.VTIQ may be a sensitive and objective method to evaluate the therapeutic effect.
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