Effects of endocrine therapy combined with Docetaxel chemotherapy on the safety and efficacy of patients with prostate cancer
Objective:To explore the effect of endocrine therapy combined with docetaxel chemotherapy on the safety and efficacy of patients with prostate cancer.Methods:120 patients with prostate cancer enrolled in our hospital from January 2020 to June 2023 were divided into control group(n=60)and study group(n=60)according to random number method.The control group was treated with endocrine therapy,and the study group was treated with endocrine therapy combined with docetaxel chemotherapy.The clinical efficacy,self-care ability,monitoring level of serum prostate-specific antigen,occurrence of adverse reactions and quality of life of patients in the two groups were evaluated.Results:The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the Cassini score and quality of life score of the study group were higher than those of the control group,and the serum prostate-specific antigen detection level was lower than that of the control group(P<0.05).There were no significant differences in the occurrence of sexual dysfunction,facial flushing,breast development and rash between the two groups(P>0.05).The incidence of neutropenia,anemia,nausea and vomiting,alopecia and liver dysfunction in the study group was higher than that in the control group(P<0.05).Conclusion:Endocrine therapy combined with docetaxel chemotherapy is effective in patients with prostate cancer,which can effectively improve patients'self-care ability,serum prostate-specific antigen monitoring level,and improve patients'quality of life,but there are many adverse reactions.
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