Objective:To observe the clinical efficacy of Shenque Acupoint application therapy on constipation after total knee arthroplasty.Methods:112 patients who received total knee arthroplasty in Guangzhou Orthopedic Hospital from January 2020 to December 2022 were selected and randomly divided into control group and treatment group.The control group received routine preventive measures,including early functional exercise,rational diet and abdominal massage after operation.Shenque Acupoint application therapy with Sihuang powder was add in the treatment group.The nurse daily evaluated the patients'abdominal exhaust,defecation,Wexner score and cared for them until discharged.The first postoperative abdominal exhaust time,the the first postoperative defecation time,the total defecation times in 5 day afert surgery,and the wexner score in the 7th day after surgeru were recorded.Results:The first postoperative exhaust time was(18.85±2.35)h in the control group while(16.67±1.63)h in the treatment group.The first postoperative defecation time was 3.30±0.76 days in the control group while 1.42±0.59 days in the treatment group.The total defecation times in 5 day afert surgery was 1.35±0.48 times in the control group and 2.50±0.53 times in the treatment group.Compared the results of two group,3.57%of patients were excellent in the control group while 55.35%in the treatment group.91.07%of patients were good in control group while 42.85%in treatment group;5%of the patients were noneffective in control group while 1.78%in treatment group;the wexner score in the 7th day aftre surgery was 9.46±3.03 in treatment group while 7.82±3.31 in treatment group.Conclusion:The Shenque Acupoint application therapy with Sihuang powder treating constipation after total knee arthroplasty is simple,non-invasive and safe.It is effective,and suitable for clinical application.