Objective:To analyze the effect of Vonoprazan fumarate combined with endoscopic hemostasis on helicobacter pylori(Hp)-associated duodenal ulcer and its effect on inflammatory factors.Methods:108 patients with Hp-associated duodenal ulcer admitted to Shantou Central Hospital from January 2022 to April 2023 were selected as the study objects.According to different treatment regimens,the patients were divided into experimental group(n=60)and control group(n=48).Both groups were given Hp eradication therapy,the control group was combined with digestive endoscope injection of norepinephrine solution,and the experimental group was combined with oral Vonoprazan fumarate tablet on the basis of the control group.The therapeutic effect,secretion of gastrin(GAS),ulcer tissue inflammatory factors[Caspase-1,NOd-like receptor protein 3(NLRP3),interleukin-18(IL-18),interleukin-1β(IL-1β)],Hp eradication rate,Hp reinfection rate and incidence of adverse reactions were compared between the two groups.Results:The effective rate of the experimental group was better than that of the control group,the difference was statistically significant(P<0.05).The levels of GAS levels in both groups after treatment were lower than before treatment,and the experimental group was lower than the control group,the differences were statistically significant(P<0.05).Serum Caspase-1,NLRP3,IL-18 and IL-1β levels in 2 groups after treatment were lower than before treatment,and the experimental group was lower than the control group,the differences were statistically significant(P<0.05).Hp eradication rate of experimental group was better than control group,the difference was statistically significant(P<0.05).There was no significant difference in Hp reinfection rate and incidence of adverse reactions between the two groups(P>0.05).Conclusion:Vonoprazan combined with endoscopic hemostasis has good effect in the treatment of Hp-associated duodenal ulcer,which can inhibit the secretion of gastric acid and regulate the level of inflammatory factors,and accelerate the recovery of patients.
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