Relationship between miR-27a and miR-23a expression levels in peripheral blood monocytes and coronary artery culprit plaques in patients with STEMI
Objective:This study aims to analyze the correlation between miR-23a and 27A expression levels in peripheral blood mononuclear cell of STEMI patients and parameters related to coronary culprit plaques measured by IVUS after PCI,in order to provide new targets for the diagnosis and treatment of STEMI patients.Methods:A total of 95 STEMI patients(92 IVUS)and 30 controls were enrolled in this study,miR-23a and 27A expression levels in peripheral blood mononuclear cell of both groups were tested and the correlation between miR-23a and 27A expression levels of STEMI patients and parameters related to coronary culprit plaques measured by IVUS after PCI were analyzed.Results:The expression levels of miR-23a and miR-27a in peripheral blood monocytes of STEMI patients were significantly higher than those of the control group(7.12±3.82 vs 1.00±0.23,P<0.000 1;10.25±4.68 vs 1.00±0.33,P<0.000 1);moreover,the expression levels of miR-23a and miR-27a in peripheral blood monocytes of STEMI patients were negatively correlated with minimal lumen area(r=-0.899 1,P<0.01;r=-0.904 3,P<0.01)and positively correlated with plaque burden(r=0.894 4,P<0.01;r=0.917 4,P<0.01).The expression levels of miR-23a and miR-27a in TCFA group were significantly higher than those in non-TCFA group(8.35±2.19 vs 5.23±1.84,P<0.000 1;12.33±2.16 vs 7.38±2.49,P<0.000 1).Conclusion:The expression levels of miR-27a and miR-23a in peripheral blood mononuclear cells of patients and PCI intraoperative by IVUS determination of significant correlation between coronary culprit plaque related parameters,patients with smaller minimal lumen area,heavier plaque burden and more obvious TCFA had higher expression levels of miR-27a and miR-23a in peripheral blood monocytes.This study provides new markers for early diagnosis of STEMI patients,strategic support for interventional diagnosis and treatment,and new targets for long-term treatment of patients.
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