Effects of different doses of dexmedetomidine combined with sufentanil or butorphanol on postoperative analgesia in patients with gastrointestinal tumors
Objective:To investigate the effect of different doses of dexmedetomidine combined with sufentanil or butorphanol on postoperative analgesia in patients with gastrointestinal tumors.Methods:A total of 120 patients with gastrointestinal tumors admitted to Luodian Hospital of Baoshan District,Shanghai from October 2021 to October 2023 were collected and divided into 4 groups by random number table method,with 30 cases in each group.Four groups were treated with different postoperative patient-controlled intravenous analgesia(PCIA)regimens:group A was 1.5 μg/kg dexmedetomidine combined with butorphanol 10 mg,group B was 2.0 μg/kg dexmedetomidine combined with butorphanol 10 mg,group C was 1.5 μg/kg dexmedetomidine combined with sufentanil 100 μg,group D was 2.0 μg/kg dexmedetomidine combined with sufentanil 100 μg.The analgesic effect,postoperative recovery and adverse reactions of the four groups were compared.Results:At 6,12,24,48 and 72 h after operation,the visual analogue scale(VAS)score of group B was gradually decreased,which was significantly lower than those of the other three groups at the same time point(all P<0.05).Compared with 6 h after operation,the VAS scores of group A,group C and group D were significantly decreased at 24,48 and 72 h after operation(all P<0.05).The postoperative anal exhaust time and postoperative analgesia pump pressing times in group B were significantly lower than those in the other three groups,and the postoperative analgesia pump pressing times in group D were significantly lower than those in group A and group C(all P<0.05).There was no significant difference in the incidence of adverse reactions among the four groups(all P>0.05).Conclusion:Postoperative high-dose dexmedetomidine combined with butorphanol intravenous patient-controlled analgesia has a good clinical effect and which is worthy of popularizing.
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