[目的]观察加味蛇黄膏(由蛇床子、黄柏、花椒等中药组成)治疗面部脂溢性皮炎的临床疗效.[方法]将72例面部脂溢性皮炎患者随机分为观察组和对照组,每组各36例.2组患者均给予口服阿伐斯汀胶囊、维生素B6片治疗,在此基础上,观察组给予加味蛇黄膏外用治疗,对照组给予2%酮康唑乳膏外用治疗,疗程均为4周.观察2组患者治疗前后临床症状积分、皮肤病生活质量指数(dermatology life quality index,DLQI)评分的变化情况,并评价2组患者的临床疗效和安全性.[结果](1)治疗4周后,观察组的总有效率为88.89%(32/36),对照组为72.22%(26/36),组间比较,观察组的疗效明显优于对照组,差异有统计学意义(P＜0.05).(2)治疗后,2组患者的红斑、鳞屑、油脂、皮疹面积、瘙痒程度等临床症状积分均较治疗前明显降低(P＜0.05),且观察组治疗后的各项临床症状积分均明显低于对照组,差异均有统计学意义(P＜0.05).(3)治疗后,2组患者的DLQI评分均较治疗前明显降低(P＜0.05),且观察组患者治疗后的DLQI评分明显低于对照组,差异有统计学意义(P＜0.05).(4)治疗期间,2组患者均无明显不良反应发生,具有较高的安全性.[结论]在常规西药治疗基础上联合加味蛇黄膏外用治疗面部脂溢性皮炎疗效确切,可有效缓解患者临床症状,提高患者生活质量.
Clinical Observation on Modified Shehuang Ointment for the Treatment of Facial Seborrheic Dermatitis
Objective To observe the clinical efficacy of modified Shehuang Ointment(mainly composed of Cnidii Fructus,Phellodendri Chinensis Cortex,and Zanthoxyli Pericarpium)for the treatment of facial seborrheic dermatitis(SD).Methods Seventy-two patients with facial SD were randomly divided into observation group and control group,with 36 patients in each group.Both groups of patients were given oral use of Acrivastine Capsules and Vitamin B6 Tablets,and additionally,the observation group was given topical application of modified Shehuang Ointment and the control group was given topical application of 2%Ketoconazole cream.The course of treatment covered 4 weeks.The changes of clinical symptom scores and dermatology life quality index(DLQI)scores in the two groups were observed before and after treatment,and the clinical efficacy and safety of the two groups were also evaluated.Results(1)After 4 weeks of treatment,the total effective rate of the observation group was 88.89%(32/36),and that of the control group was 72.22%(26/36).The intergroup comparison showed that the efficacy of the observation group was significantly superior to that of the control group,and the difference was statistically significant(P＜0.05).(2)After treatment,the clinical symptom scores of erythema,scales,grease,rash area,itchiness and other clinical symptoms of the patients in the two groups were significantly decreased compared with those before treatment(P＜0.05),and the clinical symptom scores of the observation group were significantly lower than those of the control group,the differences being statistically significant(P＜0.05).(3)After treatment,the DLQI scores of patients in the two groups were significantly lower than those before treatment(P＜0.05),and the DLQI scores in the observation group were significantly lower than those in the control group after treatment,the difference being statistically significant(P＜0.05).(4)During the treatment period,no significant adverse reactions occurred in the two groups of patients,with high safety.Conclusion The conventional western medicine treatment combined with topical application of modified Shehuang Ointment exerts certain effect in the treatment of facial SD,which can effectively relieve the clinical symptoms and improve the quality of life of patients.
modified Shehuang ointmentseborrheic dermatitis(SD)Ketoconazole creamclinical efficacyquality of life
NETL
NSTL
万方数据
维普
