芪参益气滴丸对急性心肌梗死经皮冠状动脉介入术后患者临床疗效的影响

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中文摘要：[目的]观察芪参益气滴丸(由黄芪、丹参、三七、降香等中药组成)对急性心肌梗死经皮冠状动脉介入(percutaneous coronary intervention,PCI)术后患者临床疗效的影响.[方法]将60例符合纳入标准的急性心肌梗死PCI术后气虚血瘀证患者随机分为治疗组和对照组,每组各30例.对照组给予常规西药治疗,治疗组在对照组的基础上加用芪参益气滴丸治疗,疗程为3个月.观察2组患者治疗前后心功能指标及血清超敏C反应蛋白(hs-CRP)、N末端B型利钠肽前体(NT-pro BNP)水平的变化情况,比较2组患者治疗期间心血管不良事件的发生情况.[结果](1)治疗后,2组患者血清hs-CRP、NT-pro BNP水平均较治疗前明显下降(P＜0.05),左室射血分数(LVEF)均较治疗前明显提高(P＜0.05),且治疗组对血清hs-CRP、NT-pro BNP水平的下降作用及对LVEF的提高作用均明显优于对照组,差异均有统计学意义(P＜0.05).(2)治疗期间,治疗组患者的心血管不良事件发生率为6.67%(2/30),明显低于对照组的26.67%(8/30),组间比较,差异有统计学意义(P＜0.05).[结论]芪参益气滴丸能有效改善急性心肌梗死PCI术后气虚血瘀证患者的心功能,降低血清hs-CRP及NT-pro BNP水平,减少心血管不良事件的发生.

外文标题：Influence of Qishen Yiqi Guttate Pills on the Clinical Efficacy of Patients with Acute Myocardial Infarction After Percutaneous Coronary Intervention

外文摘要：Objective To observe the influence of Qishen Yiqi Guttate Pills(mainly composed of Astragali Radix,Salviae Miltiorrhizae Radix et Rhizoma,Notoginseng Radix et Rhizoma,and Dalbergiae Odoriferae Lignum)on the clinical efficacy of patients with acute myocardial infarction after percutaneous coronary intervention(PCI).Methods Sixty post-PCI patients with acute myocardial infarction of qi deficiency and blood stasis type who met the inclusion criteria were randomly divided into a treatment group and a control group,with 30 patients in each group.The control group was treated with conventional western medicine,and the treatment group was treated with Qishen Yiqi Guttate Pills on the basis of treatment for the control group.The course of treatment for the two groups lasted for 3 months.The changes of cardiac function indicators and serum levels of hypersensitive C-reactive protein(hs-CRP)and N-terminal B-type natriuretic peptide precursor(NT-pro BNP)were observed before and after the treatment in the two groups,and the incidence of cardiovascular adverse events during the treatment in the two groups were also compared.Results(1)After treatment,the serum hs-CRP and NT-pro BNP levels of patients in the two groups were significantly decreased(P＜0.05)and the left ventricular ejection fraction(LVEF)was significantly increased(P＜0.05)compared with those before treatment.And the effects on lowering the levels of serum hs-CRP and NT-pro BNP and on increasing LVEF of the treatment group were significantly superior to those of the control group,the differences being statistically significant(P＜0.05).(2)During the treatment period,the incidence of cardiovascular adverse events in the treatment group was 6.67%(2/30),which was significantly lower than 26.67%(8/30)of the control group,and the difference was statistically significant when comparing the two groups(P＜0.05).Conclusion Qishen Yiqi Guttate Pills can effectively improve cardiac function,decrease serum hs-CRP and NT-pro BNP levels,and reduce the occurrence of adverse cardiovascular events in post-PCI patients with acute myocardial infarction of qi deficiency and blood stasis type.

外文关键词：

acute myocardial infarctionpost-percutaneous coronary interventionQishen Yiqi Guttate Pillscardiac functionhypersensitive C-reactive protein(hs-CRP)N-terminal B-type natriuretic peptide precursor(NT-pro BNP)

作者：

雷金义、夏裕、欧晓红

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作者单位：

广州中医药大学,广东广州 510006

清远市中医院,广东清远 511500

关键词：

急性心肌梗死经皮冠状动脉介入术后芪参益气滴丸心功能超敏C反应蛋白(hs-CRP) N末端B型利钠肽前体(NT-pro BNP)

基金：

广东省卫生健康委项目

项目编号：

YXH2019ZXY004

出版年：

2024

DOI：

10.13359/j.cnki.gzxbtcm.2024.04.004

广州中医药大学学报

广州中医药大学

广州中医药大学学报

CSTPCD

影响因子：1.055

ISSN：1007-3213

年,卷(期)：2024.41(4)

参考文献量16