首页|岭南传统天灸4号方治疗轻度抑郁障碍的临床疗效观察

岭南传统天灸4号方治疗轻度抑郁障碍的临床疗效观察

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[目的]观察岭南传统天灸4号方(由黄芥子、吴茱萸、郁金等中药组成)治疗轻度抑郁障碍的临床疗效,为轻度抑郁障碍人群的治疗提供新的临床思路.[方法]将61例轻度抑郁障碍患者随机分为试验组31例和对照组30例.试验组给予岭南传统天灸4号方天灸治疗,对照组给予岭南传统天灸4号方安慰剂天灸治疗.每周治疗2次,每次治疗间隔3～4 d,疗程为6周.观察2组患者治疗前后汉密尔顿抑郁量表17项(HAMD-17)评分和患者健康问卷抑郁症筛查量表(PHQ-9)评分的变化情况,并评价2组患者的临床疗效和安全性.[结果](1)疗效方面,治疗6周后,试验组的总有效率为77.42%(24/31),对照组为26.67%(8/30),组间比较(秩和检验),试验组的疗效明显优于对照组,差异有统计学意义(P＜0.01).(2)量表评分方面,治疗后,2组患者的HAMD-17评分和PHQ-9评分均较治疗前降低(P＜0.01),且试验组对HAMD-17评分和PHQ-9评分的降低幅度均明显优于对照组,差异均有统计学意义(P＜0.01).(3)安全性方面,研究过程中,有5例不良事件的发生与本次天灸治疗相关,且5例不良事件均发生在试验组中,均为穴位贴敷处发生轻微水泡,经相关处理后均可继续参与本次试验.[结论]岭南传统天灸4号方可以有效改善轻度抑郁障碍患者临床症状,且具有较高的安全性.
Clinical Observation on the Therapeutic Effect of Lingnan Traditional Vesiculating Moxibustion No.4 Recipe in the Treatment of Mild Depressive Disorder
Objective To observe the clinical efficacy of Lingnan Traditional Vesiculating Moxibustion No.4 Recipe(mainly composed of Brassicae Junceae Semen,Euodiae Fructus,and Curcumae Radix)in the treatment of mild depressive disorder(DD),and to provide a novel approach to the treatment of mild DD population.Methods Sixty-one patients with mild DD were randomly divided into 31 cases in the trial group and 30 cases in the control group.The trial group was given medicinal vesiculation treatment with Lingnan Traditional Vesiculating Moxibustion No.4 Recipe,and the control group was given medicinal vesiculation treatment with the placebo of Lingnan Traditional Vesiculating Moxibustion No.4 Recipe.The treatment was performed twice a week and with an interval of 3-4 days between the treatment,and the course of treatment covered 6 weeks.The changes of Hamilton Depression Scale-17(HAMD-17)scores and Patient Health Questionnaire-9(PHQ-9)scores in the two groups were observed before and after the treatment.After treatment,the clinical efficacy and safety of the patients in the two groups were evaluated.Results(1)After 6 weeks of treatment,the total efficacy rate of the trial group was 77.42%(24/31),and that of the control group was 26.67%(8/30).The intergroup comparison(tested by rank sum test)showed that the efficacy of the trial group was significantly superior to that of the control group,and the difference was statistically significant(P＜0.01).(2)After treatment,the HAMD-17 scores and PHQ-9 scores of patients in the two groups were lower than those before treatment(P＜0.01),and the decrease of HAMD-17 and PHQ-9 scores in the trial group was significantly superior to that of the control group,the difference being statistically significant(P＜0.01).(3)During the trial,there were 5 cases of adverse events related to the vesiculating moxibustion treatment,and all 5 cases of adverse events occurred in the trial group,manifested as minor blisters at the acupoint application region.The 5 cases kept on participating in the trial after relevant treatment.Conclusion Lingnan Traditional Vesiculating Moxibustion No.4 Recipe can effectively relieve the clinical symptoms of patients with mild DD,and has high safety.

vesiculating moxibustionLingnan Traditional Vesiculating Moxibustion No.4 Recipedepressive disorderclinical efficacysafety

周忆蓉、方慧、张琬欣、吉祥、符文彬

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广州中医药大学第七临床医学院针灸科,广东深圳 518100

广东省中医院针灸科,广东广州 510120

天灸 岭南传统天灸4号方 抑郁障碍 临床疗效 安全性

广东省自然科学基金广东省自然科学基金广东省重点领域研发计划岭南中医药现代化重点专项深圳宝安区针灸临床研究中心项目深圳市医疗卫生"三名工程"广东省中医院符文彬教授针灸学团队项目

2019A15150120432018A0303105312020B1111100007BAZJ2018239SZSM201806077

2024

10.13359/j.cnki.gzxbtcm.2024.04.022

广州中医药大学学报
广州中医药大学

广州中医药大学学报

CSTPCD
影响因子：1.055
ISSN：1007-3213
年,卷(期)：2024.41(4)
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