Investigation on Correlation of Yang Deficiency and Blood Stasis Syndrome with Cardiac Function and Serum NT-proBNP Expression in Chronic Heart Failure Patients and Their Influence on Prognosis
Objective To investigate the correlation of yang deficiency and blood stasis syndrome with cardiac function and serum B-type N-terminal pro-brain natriuretic peptide(NT-proBNP)expression in patients with chronic heart failure and their influence on the prognosis of patients.Methods A total of 320 patients with chronic heart failure admitted to Tangshan Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were selected as the research objects.According to the results of traditional Chinese medicine(TCM)syndrome differentiation,160 patients differentiated as yang deficiency and blood stasis syndrome were allocated to the observation group,and 160 patients differentiated as qi deficiency and blood stasis syndrome or qi and yin deficiency syndrome were allocated to the control group.The patients with chronic heart failure of yang deficiency and blood stasis syndrome were followed up for one year after discharge.Based on the follow-up results,the followed-up patients were divided into good prognosis group(104 cases)and poor prognosis group(56 cases).Spearman correlation analysis was used to analyze the correlation of TCM syndromes with serum NT-proBNP levels and cardiac function indicators such as left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),stroke volume per minute(SV),and cardiac output(CO).Multivariate logistic regression analysis was used to explore the risk factors affecting the poor prognosis of patients.Results(1)The serum NT-proBNP level and LVEDD value of the observation group were significantly higher and the LVEF,SV and CO values were lower than those of the control group,and the differences were statistically significant(P＜0.05 or P＜0.01).(2)Pearson correlation analysis showed that TCM syndromes in patients with chronic heart failure were positively correlated with serum NT-proBNP level and LVEDD value,and were negatively correlated with LVEF,SV and CO values,the differences being statistically significant(P＜0.01).(3)The levels of serum NT-proBNP and LVEDD in the poor prognosis group were significantly higher and the values of LVEF,SV and CO were lower than those in the good prognosis group,and the differences were statistically significant(P＜0.01).(4)The area under the curve(AUC)of serum NT-proBNP combined with cardiac function indicators for predicting the poor prognosis was 0.942.Logistic regression analysis showed that high levels of serum NT-proBNP and LVEDD were the risk factors for poor prognosis(P＜0.01),while high levels of LVEF,SV and CO were the protective factors(P＜0.05 or P＜0.01)in the patients with chronic heart failure of yang deficiency and blood stasis syndrome.Conclusion The serum NT-proBNP level in patients with chronic heart failure of yang deficiency and blood stasis syndrome is increased.Yang deficiency and blood stasis syndrome is closely related to the serum NT-proBNP level and cardiac function indicators,and NT-proBNP level and cardiac function indicators are correlated with the prognosis of the patients.
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