Exploration on the Role of Astragali Radix Injection in Treating Chronic Heart Failure from the Perspective of Myocardial Remodeling and Cardiac Function Markers NT-proBNP and H-FABP Levels
Objective To investigate the effect of Astragali Radix Injection on chronic heart failure(CHF)from the Perspective of myocardial remodeling and the levels of cardiac function markers of N-terminal pro-brain natriuretic peptide(NT-ProBNP)and heart-type fatty acid binding protein(H-FABP).Methods A total of 80 CHF patients with heart qi deficiency syndrome were randomly divided into control group and study group,with 40 cases in each group.The control group was treated with routine western medicine,and the study group was treated with Astragali Radix Injection on the basis of treatment for the control group.The course of treatment covered one week.The changes of Lee's heart failure score,traditional Chinese medicine(TCM)syndrome score,Minnesota Living with Heart Failure Questionnaire(MLHFQ)score and 6-minute walking distance(6MWD)in the two groups were observed before and after treatment.Moreover,the changes of cardiac function indicators such as left ventricular ejection fraction(LVEF),stroke volume(SV)and left ventricular end-diastolic diameter(LVEDD)as well as the serum levels of cardiac function markers of NT-proBNP and H-FABP in the two groups before and after treatment were detected.After treatment,the clinical efficacy of the two groups was evaluated.Results(1)After one week of treatment,the total effective rate of the study group was 90.00%(36/40),and that of the control group was 62.50%(25/40).The intergroup comparison(tested by chi-square test)showed that the efficacy of the study group was significantly superior to that of the control group(P＜0.01).(2)After treatment,the outcomes of Lee's heart failure score,TCM syndrome score and MLHFQ score of the two groups were significantly lower than those before treatment(P＜0.01),and the decrease of the scores in the study group was significantly superior to that in the control group(P＜0.01).(3)After treatment,the 6MWD of the two groups was significantly increased compared with that before treatment(P＜0.05 or P＜0.01),and the increase of 6MWD in the study group was significantly superior to that in the control group(P＜0.05).(4)After treatment,the serum levels of laboratory indicators of NT-proBNP and H-FABP in the two groups were significantly lower than those before treatment(P＜0.01),and the decrease in the study group was significantly superior to that in the control group(P＜0.01).(5)After treatment,the levels of cardiac function indicators of LVEF and SV in the two groups were significantly increased compared with those before treatment(P＜0.01),and the increase in the study group was significantly superior to that in the control group(P＜0.01).However,LVEDD in the two groups after treatment did not differ from that before treatment,no significant difference of LVEDD was shown between the two groups after treatment,either(P＞0.05).Conclusion On the basis of conventional western medicine treatment,the application of Astragali Radix Injection exerts certain curative effect for the treatment of CHF of heart qi deficiency type.The combined therapy is effective on alleviating the clinical symptoms of patients and improving the heart function and the quality of life of the patients.
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