Observation on the Curative Effect of Chaihu Shugan Powder and Danshen Decoction on Patients with Anxiety and Depression of Qi Stagnation and Blood Stasis Type After Percutaneous Coronary Intervention for Coronary Heart Disease
Objective To observe the clinical efficacy and safety of Chaihu Shugan Powder and Danshen Decoction in the treatment of patients with anxiety and depression of qi stagnation and blood stasis type after percutaneous coronary intervention(PCI)for coronary atherosclerotic heart disease(shortened as"coronary heart disease",CHD).Methods Sixty patients with anxiety and depression of qi stagnation and blood stasis type after PCI for CHD were randomly divided into a control group and an observation group,30 cases in each group.Both groups were given medicines for standard secondary prevention after PCI for CHD.Additionally,the observation group was treated with Chaihu Shugan Powder and Danshen Decoction for 4 weeks.The changes in the scores of traditional Chinese medicine(TCM)syndrome,9-item Patient Health Questionnaire(PHQ-9),Generalized Anxiety Disorder Scale(GAD-7),Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale 17-item(HAMD-17)in the two groups were observed before and after treatment.After treatment,the efficacy for the improvement of anxiety and depression,TCM syndrome efficacy and clinical safety were evaluated in the two groups.Results(1)After 4 weeks of treatment,the total effective rates for the improvement of anxiety and depression in the observation group were 86.67%(26/30)and 90.00%(27/30),respectively,while those in the control group were 40.00%(12/30)and 56.67%(17/30),respectively.The intergroup comparison(tested by chi-square test)showed that the improvement of anxiety and depression in the observation group was significantly superior to that in the control group(P＜0.05).(2)After 4 weeks of treatment,the total effective rate for the improvement of TCM syndromes in the observation group was 93.33%(28/30),and that in the control group was 53.33%(16/30).The intergroup comparison(tested by chi-square test)showed that the efficacy for the improvement of TCM syndromes in the observation group was significantly superior to that in the control group(P＜0.05).(3)After treatment,the scores of TCM syndromes,PHQ-9,GAD-7,HAMA and HAMD-17 in the two groups were significantly lower than those before treatment(P＜0.01),and the decrease in the observation group was significantly superior to that in the control group(P＜0.01).(4)During the treatment,there were no obvious adverse reactions occurring in the two groups,and there were no abnormalities in the safety indicators such as vital signs,blood routine test and liver and kidney function indicators of the patients,showing high safety.Conclusion On the basis of conventional western medicine treatment,Chaihu Shugan Powder combined with Danshen Decoction can significantly improve the clinical symptoms and anxiety and depression of qi stagnation and blood stasis type in the patients after PCI for CHD,reduce TCM syndrome scores,and improve the quality of life of patients.
coronary atherosclerotic heart diseasepercutaneous coronary intervention(PCI)anxiety and depressionqi stagnation and blood stasis typeChaihu Shugan PowderDanshen Decoction
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