Clinical Observation on the Tiaodu Lijin Acupuncture Combined with Thumb-tack Needling for Subcutaeous Embedding in the Treatment of Lumbar Disc Herniation
Objective To observe the clinical efficacy of Tiaodu Lijin Acupuncture combined with thumb-tack needling for subcutaeous embedding in the treatment of lumbar disc herniation.Methods A total of 98 patients with lumbar disc herniation were randomly divided into observation group and control group,49 cases in each group.The control group was treated with Tiaodu Lijin Acupuncture,and the observation group was treated with thumb-tack needling for subcutaeous embedding on the basis of the control group.Both groups were treated for one month.After one month of treatment,the clinical efficacy of the two groups was evaluated.The changes of Japanese Orthopaedic Association(JOA)score and Visual Analogue Scale(VAS)of pain were observed before and after treatment in the two groups,as well as the activity of lumbar spine and the expressions of ERK protein and ERK mRNA.The levels of β-endorphin(β-EP),neuropeptide Y(NPY),5-hydroxytryptamine(5-HT),substance P(SP),interleukin 6(IL-6),tumor necrosis factor α(TNF-α)and interleukin 1β(IL-1β)were compared between the two groups before and after treatment.The safety of the two groups was evaluated.Results(1)The total effective rate was 93.88%(46/49)in the observation group and 79.59%(39/49)in the control group.The curative effect of the observation group was superior to that of the control group,and the difference was statistically significant(P＜0.05).(2)After treatment,the JOA and VAS scores of the two groups were significantly improved(P＜0.05),and the improvement of JOA and VAS scores in the observation group was significantly superior to that in the control group,the difference was statistically significant(P＜0.05).(3)After treatment,the levels of β-EP,NPY,5-HT and SP in the two groups were significantly improved(P＜0.05),and the observation group was significantly superior to the control group in improving the levels of β-EP,NPY,5-HT and SP,the difference was statistically significant(P＜0.05).(4)After treatment,the levels of IL-6,IL-1β and TNF-α in the two groups were significantly improved(P＜0.05),and the levels of IL-6,IL-1β and TNF-α in the observation group were significantly superior to those in the control group(P＜0.05).(5)After treatment,the lumbar flexion and extension activities of the two groups were significantly improved(P＜0.05),and the improvement of lumbar flexion and extension activities in the observation group was significantly superior to that in the control group,the difference was statistically significant(P＜0.05).(6)After treatment,the expressions of ERK protein and the level of ERK mRNA in the two groups were significantly improved(P＜0.05),and the observation group was significantly superior to the control group in improving the expressions of ERK protein and the level of ERK mRNA,the difference was statistically significant(P＜0.05).(7)The incidence of adverse reactions in the observation group was 8.16%(4/49),while the control group was 4.08%(2/49).There was no significant difference between the observation group and the control group(P＞0.05).Conclusion Tiaodu Lijin Acupuncture combined with thumb-tack needling for subcutaeous embedding exerts certain effect in the treatment of lumbar disc herniation.It can significantly improve the pain symptoms of patients,reduce the levels of serum pain mediators and inflammatory factors,and improve lumbar function.The mechanism may be related to the inhibition of ERK signaling pathway.
Tiaodu Lijin Acupuncturethumb-tack needling for subcutaeous embeddinglumbar disc herniationextracellular regulatory protein kinase(ERK)pain mediatorclinical observation
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