首页|铁死亡与骨质疏松症及中医药通过铁死亡机制防治骨质疏松症的研究进展

铁死亡与骨质疏松症及中医药通过铁死亡机制防治骨质疏松症的研究进展

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铁死亡是一种不同于细胞凋亡、细胞坏死的新型细胞程序性死亡方式,其机制涉及铁代谢异常所致的铁超载及脂质过氧化和活性氧生成.铁死亡与原发性骨质疏松症及继发性骨质疏松症如类固醇诱导的骨质疏松症、糖尿病性骨质疏松症和绝经后骨质疏松症的形成有关.通过铁死亡机制防治骨质疏松症的中药主要涉及中药复方如杜仲-续断药对、金天格胶囊、补骨生髓方等,以及单味中药如牛膝及中药有效成分如淫羊藿苷、天麻素、槲皮素、青蒿琥酯等.中药单体以及中药复方防治骨质疏松症可通过多靶点、多通路抑制铁死亡,目前中药在防治绝经后骨质疏松症方面较有优势.通过调节铁死亡机制而防治骨质疏松症可为未来中药防治骨质疏松症的研究提供方向.
Research Progress in Ferroptosis and Osteoporosis,and the Prevention and Treatment of Osteoporosis by Chinese Medicine Through Ferroptosis Mechanism
Ferroptosis is a new type of programmed cell death different from apoptosis and necrosis.Its mechanism involves iron overload,lipid peroxidation,and reactive oxygen species(ROS)generation caused by disordered iron metabolism.Ferroptosis is associated with primary osteoporosis as well as the secondary osteoporosis such as steroid-induced osteoporosis,diabetic osteoporosis and postmenopausal osteoporosis.The Chinese medicines for the prevention and treatment of osteoporosis through the mechanism of ferroptosis mainly involve Chinese herbal compounds such as herbal pair of Eucommiae Cortex-Dipsaci Radix,Jintiange Capsules,and Bugu Shengsui Prescription,the single Chinese herbal medicine of Achyranthis Bidentatae Radix,and the active ingredients of herbal medicines such as icariin,gastrodin,quercetin,and artesunate.The prevention and treatment of osteoporosis by Chinese medicine monomer and Chinese herbal compound can inhibit ferroptosis through multiple targets and multiple pathways.At present,Chinese medicine has advantages in the prevention and treatment of postmenopausal osteoporosis.The prevention and treatment of osteoporosis by regulating the mechanism of ferroptosis can provide a direction for the future research on the prevention and treatment of osteoporosis by Chinese medicine.

osteoporosisferroptosisiron overloadlipid peroxidationreactive oxygen speciesAchyranthis Bidentatae RadixicariingastrodinChinese medicinereview

谢伟、王高祥、鄢羽欣、楚淑芳、刘德亮、刘雪梅

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广州中医药大学第四临床医学院,广东深圳 518000

深圳市中医院,广东深圳 518000

南京中医药大学附属深圳市中医院,广东深圳 518000

骨质疏松症 铁死亡 铁超载 脂质过氧化 活性氧 牛膝 淫羊藿苷 天麻素 中医药 综述

国家自然科学基金资助项目广东省自然科学基金资助项目深圳市科技创新委员会资助项目

821047592019A1515110108JCYJ20170817094838619

2024

10.13359/j.cnki.gzxbtcm.2024.07.041

广州中医药大学学报
广州中医药大学

广州中医药大学学报

CSTPCD
影响因子：1.055
ISSN：1007-3213
年,卷(期)：2024.41(7)
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