Clinical Efficacy of Bailian Zhiwei Prescription in Treating Chronic Atrophic Gastritis and Its Effect on Serum Pepsinogen Expression Level
Objective To investigate the clinical efficacy of modified Bailian Zhiwei Prescription(mainly composed of Hedyotis Diffusae Herba,Scutellariae Barbatae Herba,Fici Simplicissimae Radix,Salviae Miltiorrhizae Radix et Rhizoma,Curcumae Radix,Atractylodis Macrocephalae Rhizoma,Galli Gigerii Endothelium Corneum,Corydalis Rhizoma,Curcumae Rhizoma,Citri Reticulatae Pericarpium,Cortex Magnoliae Officinalis,and Glycyrrhizae Radix et Rhizoma)in the treatment of chronic atrophic gastritis(CAG),and to observe its effect on serum pepsinogen expression level.Methods Sixty-four patients with CAG of spleen deficiency with damp-heat and stasis obstruction type were randomly divided into a control group and a treatment group,with 32 patients in each group.The control group was treated with Moluodan Pills,and the treatment group was treated with the modified Bailian Zhiwei Prescription.Both groups were treated for a period of 2 months.The changes of the primary traditional Chinese medicine(TCM)syndrome scores,staging scores of gastric mucosa under gastroscopy evaluated with the operative link for gastritis assessment(OLGA),and serum pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)levels as well as PGⅠ/PGⅡratio(PGR)in the patients of the two groups were observed before and after the treatment.We also evaluated the clinical efficacy of the two groups after treatment.Results(1)After 2 months of treatment,the total effective rate of the treatment group was 96.88%(31/32),and that of the control group was 81.25%(26/32),and the intergroup comparison showed that the total effective rate(tested by chi-square test)and overall therapeutic efficacy(tested by rank-sum test)of the treatment group were significantly superior to those of the control group(P<0.05).(2)After treatment,the TCM syndrome scores of epigastric flatulence,gastric stabbing pain,bitter mouth and halitosis,and fatigue in both groups were significantly decreased compared with those before treatment(P<0.01),and the decrease in the treatment group was significantly superior to that in the control group(P<0.01).(3)The analysis of the gastroscopic findings of gastric mucosa showed that after treatment,the OLGA staging scores of the two groups were lower than those before treatment(P<0.01),and the decrease in the treatment group was significantly superior to that in the control group(P<0.01).(4)After treatment,the levels of serum PGⅠand PGR in the two groups were increased compared with those before treatment(P<0.01),and the level of serum PGⅡwas decreased that before treatment(P<0.01).The increase of serum PGⅠ and PGR levels and the decrease of serum PGⅡlevel in the treatment group were significantly superior to those in the control group(P<0.01).Conclusion Modified Bailian Zhiwei Prescription exerts certain effect in treating patients with CAG of spleen deficiency with damp-heat and stasis obstruction type,which can effectively alleviate the clinical symptoms of the patients,improve the gastroscopic fingdings of gastric mucosa of the patients,and regulate the expression level of serum pepsinogen.
chronic atrophic gastritis(CAG)spleen deficiency with damp-heat and stasis obstruction typeBailian Zhiwei PrescriptionMoluodan Pillspepsinogenclinical efficacy