Effect of Bazhen Huaji Decoction on Quality of Life in Patients with Advanced Gastrointestinal Cancer
Objective To investigate the effect of Bazhen Huaji Decoction(a modified prescription of Bazhen Decoction plus Huaji Pills)on the quality of life of patients with advanced gastrointestinal cancer of qi deficiency and blood stasis type.Methods Sixty-five patients with advanced gastrointestinal cancer of qi deficiency and blood stasis type were randomly divided into an observation group(33 cases)and a control group(32 cases).The control group was treated with XELOX chemotherapy regimen(Oxaliplatin combined with Capecitabine),and the observation group was treated with Bazhen Huaji Decoction on the basis of treatment for the control group.The course of treatment covered 3 weeks,including 2 weeks of treatment and one week of follow-up.The changes of tumor marker carbohydrate antigen 199(CA199)and European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC-QLQ-C30)scores in the two groups were observed before and after treatment.Moreover,the efficacy for improving Karnofsky score and the incidence of adverse reactions were compared between the two groups.Results(1)After the completion of treatment,the rate for the increase of Karnofsky score in the observation group was 36.36%(12/33),which was higher than that in the control group(25.00%,8/32);the rate for the decrease of Karnofsky score in the observation group was 9.09%(12/33),which was lower than that in the control group(15.63%,5/32).The difference of rate for improving Karnofsky score between the two groups was statistically significant(P＜0.05).(2)After 2 weeks of treatment and during the follow-up period,the total score of overall health status and functional domain scores of EORTC-QLQ-C30 in the two groups were increased(P＜0.05)and the symptom domain scores were decreased compared with those before treatment(P＜0.05),and the increase of the total score of overall health status in the observation group during the follow-up period was significantly superior to that in the control group(P＜0.05).Subgroup analysis showed that the overall health status scores and functional domain scores of gastric cancer patients and colorectal cancer patients in the two groups after treatment and follow-up period were higher(P＜0.05)and the symptom domain scores were lower than those before treatment(P＜0.05).Moreover,the total health status scores and functional domain score of gastric cancer patients in the two groups before and after treatment and during the follow-up period were lower and the symptom scores were higher than those of the patients with colorectal cancer,and the differences were statistically significant(P＜0.05).(3)After treatment,there were no significant changes in the serum CA199 level between the two groups in comparison with that before treatment,and there was no significant difference between the two groups after treatment(P＞0.05).(4)The incidence of adverse reactions in the observation group was 48.48%(16/33),which was significantly lower than that in the control group(68.75%,22/32).The difference between the two groups was statistically significant(P＜0.05).Conclusion On the basis of conventional chemotherapy,the application of Bazhen Huaji Decoction exerts certain effect in the treatment of patients with advanced gastrointestinal cancer of qi deficiency and blood stasis type.The combined therapy can effectively reduce the incidence of adverse reactions caused by chemotherapy and improve the quality of life of patients.
Bazhen Huaji DecoctionBazhen DecoctionHuaji Pillsgastrointestinal cancerqi deficiency and blood stasis syndromeadverse reactionsquality of life
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