Observation on the Therapeutic Effect of Jianpi Shuyan Decoction Combined with Thumbtack Needling Therapy for Chronic Sore Throat of Spleen-Qi Weakness Type
Objective To explore the clinical efficacy of Jianpi Shuyan Decoction(mainly composed of Astragali Radix,Codonopsis Radix,Atractylodis Macrocephalae Rhizoma,Angelicae Sinensis Radix,Pinelliae Rhizoma Praeparatum,Cortex Magnoliae Officinalis,Bombyx Batryticatus,and Platycodonis Radix)combined with thumbtack needling therapy(treated with thumbtack-type needle for subcutaneous embedding)in the treatment of chronic sore throat,i.e.,chronic pharyngitis,of spleen-qi weakness type.Methods Sixty-eight patients with chronic pharyngitis of spleen-qi weakness type were randomly divided into the control group and the trial group,with 34 patients in each group.The two groups were given buccal use of Cydiodine Buccal Tablets,and additionally,the trial group was treated with Jianpi Shuyan Decoction combined with thumbtack needling therapy at the six acupoints for pharyngeal disease,i.e.,Futu(LI18),Yamen(GV15),Lianquan(CV23),Tiantu(CV22),Lieque(LU7),and Zhaohai(KI6).Seven days constituted one course of treatment,and the two groups were treated for a total of two courses of treatment.One month and three months after the completion of treatment,the long-term follow-up of the patients was carried out.Before and after the treatment,the changes in visual analogue scale(VAS)score of the illness,inflammatory indicators of C-reactive protein(CRP)and interleukin 2(IL-2),and traditional Chinese medicine(TCM)syndrome scores in the two groups were observed.Moreover,the clinical efficacy,recurrence rate and clinical safety of the two groups were evaluated.Results(1)During the study,2 patients in each of the two groups fell off,and finally 32 patients in each group completed the whole course of treatment.(2)After 2 weeks of treatment,the total effective rate of the trial group was 90.63%(29/32),and that of the control group was 75.00%(24/32).The total effective rate(tested by chi-square test)and overall efficacy(tested by rank sum test)of the trial group were significantly superior to those of the control group(P＜0.05).(2)After 2 weeks of treatment,the VAS score of the illness in the two groups was improved compared with that before treatment(P＜0.05),and the improvement of the VAS scores in the trial group was significantly superior to that in the control group(P＜0.05).(3)After 2 weeks of treatment,the levels of serum inflammatory indicators of CRP and IL-2 in the two groups were decreased compared with those before treatment(P＜0.05),and the decrease of serum CRP and IL-2 levels in the trial group was significantly superior to that in the control group(P＜0.05).(4)After 2 weeks of treatment and one month and three months after the completion of treatment,the TCM syndrome scores of the two groups were lower than those before treatment(P＜0.05),but the scores in the two groups one month after the completion of treatment did not differ from those three months after the completion of treatment(P＞0.05).The intergroup comparison showed that the decrease of the scores in the trial group was significantly superior to that in the control group after two weeks of treatment and one month and three months after the completion of treatment(P＜0.05).(5)During the treatment,there were no obvious adverse reactions occurring in the two groups and there were no obvious abnormalities in the safety indexes of blood routine test and liver and kidney function,with high safety.(6)The results of long-term follow-up showed that the recurrence rate of the trial group was 9.38%(3/32)and that of the control group was 18.75%(6/32),and the difference between the two groups was statistically significant(P＜0.05).With the consideration of the changes of TCM syndrome scores in the two groups,it is indicated that the long-term efficacy of the trial group was significantly superior to that of the control group.Conclusion On the basis of buccal use of Cydiodine Buccal Tablets,the application of Jianpi Shuyan Decoction combined with thumbtack needling therapy at the six acupoints for pharyngeal disease exerts certain effectin the treatment of patients with chronic pharyngitis of spleen-qi weakness type.The combined therapy is more effective on relieving clinical symptoms,inhibiting inflammatory response and maintaining long-term efficacy than Cydiodine Buccal Tablets alone.
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