首页|中药通过调控PI3K-AKT信号通路干预卵巢早衰的研究进展

中药通过调控PI3K-AKT信号通路干预卵巢早衰的研究进展

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近年来,大量研究证实磷酯酰肌醇3激酶(PI3K)/蛋白激酶B(AKT)信号通路通过调控卵巢细胞的炎症反应、细胞凋亡及自噬、氧化应激、颗粒细胞增殖等过程决定卵泡的闭锁与凋亡,已成为卵巢早衰发生与发展的关键通路.中医药在治疗卵巢早衰等慢性复杂性疾病过程中有明显的优势,而调节PI3K/AKT信号通路是其防治卵巢早衰的作用机制之一.中药可通过调控PI3K-AKT信号通路,抑制卵巢早衰发生与发展过程中的炎症反应,拮抗氧化应激,抑制细胞凋亡及细胞自噬,促进颗粒细胞增殖,从而干预卵巢早衰.该文综述了 PI3K/AKT信号通路及其上下游分子在卵巢早衰发病机制中的作用及中药通过PI3K/AKT信号通路干预POF的作用机制,以期为卵巢早衰的基础研究与新药研发提供理论依据.
Research Progress of Chinese Herbal Medicine in Intervening Premature Ovarian Failure by Regulating PI3K-AKT Signaling Pathway
In recent years,a large amount of studies have confirmed that the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway plays a decisive role in the follicular atresia and apoptosis by regulating the inflammatory response,apoptosis and autophagy,and oxidative stress of ovarian cells as well as ovarian granular cell proliferation,which is a key pathway for the occurrence and development of premature ovarian failure(POF).Traditional Chinese medicine(TCM)has obvious advantages in the treatment of chronic complex diseases such as POF,and the regulation of PI3K/AKT signaling pathway is one of the mechanisms of the prevention and treatment of POF with Chinese herbal medicine.The intervention of POF with TCM can be achieved by inhibiting the inflammatory response,counteracting oxidative stress,inhibiting apoptosis and autophagy,and promoting granular cell proliferation in the occurrence and development of POF through the regulation of the PI3K/AKT signaling pathway.This article reviewed the role of PI3K/AKT signaling pathway and its upstream and downstream molecules in the pathogenesis of POF,and explored the mechanism of TCM in intervening POF through the PI3K/AKT signaling pathway,which will provide theoretical evidence for the basic research and new drug development for POF.

premature ovarian failureChinese herbal medicinePI3K/AKT signaling pathwayinflammatory responseapoptosisautophagyoxidative stresscell proliferationreview

赵永涵、马红丽、杨新鸣

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黑龙江中医药大学研究生院,黑龙江哈尔滨 150040

黑龙江中医药大学附属第一医院,黑龙江哈尔滨 150040

卵巢早衰 中药 PI3K/AKT信号通路 炎症反应 细胞凋亡 自噬 氧化应激 细胞增殖 综述

国家自然科学基金青年基金项目中国中医科学院技术创新工程重大攻关项目

82004403CI2021A00404

2024

10.13359/j.cnki.gzxbtcm.2024.09.041

广州中医药大学学报
广州中医药大学

广州中医药大学学报

CSTPCD
影响因子：1.055
ISSN：1007-3213
年,卷(期)：2024.41(9)