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从标到本:论银屑病复发之本质

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银屑病复发一直是银屑病治疗中的难点,且随着生物制剂的广泛应用,这一问题未来会更突出.该课题组从银屑病的"脾肾阳虚是其根本,外邪触发是其诱因,血热瘀滞是其标象"的"本虚标实"病机观出发,提出银屑病的本质是一类内伤性疾病,银屑病的反复发作与其"以血热瘀阻为标,以脾肾亏虚为本"的病机特点密切相关;复发是因治疗手段仅抑制了"血热"之标象,而未能修复亏虚之本.故在银屑病的治疗中,固本之法应当贯穿始终,并结合其水湿停留、瘀血结滞之标实,重视祛湿与化瘀,方能取得更加稳定的整体疗效.
From Symptoms to the Root Cause:Analyzing the Essence of Psoriasis Recurrence
The recurrence of psoriasis has always been a difficult problem in the treatment of psoriasis,and with the widely use of biological agents,this problem will become more prominent in the future.The pathogenesis of psoriasis is characterized by deficiency in the origin and excess in the superficiality,manifesting that spleen-kidney yang deficiency is the root cause of psoriasis,triggered external pathogens is the predisposing factor of psoriasis,and blood-heat and stasis obstruction becomes the secondary symptoms of psoriasis.In this article,it is proposed that psoriasis is a kind of diseases of internal injury in nature,and the recurrence of psoriasis is closely related to the pathogenesis of'blood-heat and stasis obstruction as the secondary symptoms,and spleen-kidney deficiency as the root cause'.The recurrence is due to the fact that the treatment only suppresses the secondary symptoms of blood heat but fails to eliminate the root cause of depletion and deficiency.Therefore,the therapy of consolidating vital base should be performed throughout the treatment of psoriasis,and the methods of eliminating dampness and removing stasis should be adopted depending on the presence of water-dampness retention and blood stasis stagnation,so as to achieve the overall stable therapeutic effect.

psoriasisrelapseetiology and pathogenesisdeficiency in the origin and excess in the superficialityconsolidating vital baseeliminating dampnessremoving stasis

郭洁、卢传坚

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广州中医药大学第二临床医学院,广东广州 510405

广州中医药大学第二附属医院岭南补土学术流派研究室,广东广州 510120

粤港澳中医药与免疫疾病研究联合实验室,广东广州 510120

银屑病 复发 病因病机 本虚标实 固本 祛湿 化瘀

国家自然科学基金集成项目国家自然科学基金重点支持项目国家中医药管理局中医药创新团队及人才支持计划项目

U23A6012U20A20397ZYYCXTD-C-202204

2024

10.13359/j.cnki.gzxbtcm.2024.10.017

广州中医药大学学报
广州中医药大学

广州中医药大学学报

CSTPCD
影响因子：1.055
ISSN：1007-3213
年,卷(期)：2024.41(10)