Effect of Pingtiao Granules on Blood Pressure Variability in Patients with Hypertension Complicated by Sleep Disorders:A Retrospective Study
Objective To investigate the effects of Pingtiao Granules combined with conventional western medical treatment on blood pressure variability(BPV)and sleep quality in patients with hypertension complicated by sleep disorders of liver yang hyperactivity type.Methods A retrospective study was carried out in 152 patients with hypertension complicated by sleep disorders of liver yang hyperactivity type who were treated in Guangdong Second Traditional Chinese Medicine Hospital from December 2020 to December 2023.According to the treatment regimen,the patients were divided into the control group and the observation group,with 76 cases in each group.The control group was given Valsartan alone for antihypertensive therapy,and the observation group was treated with Pingtiao Granules on the basis of treatment for the control group.The course of treatment for the two groups covered four weeks.Before and after treatment,the changes of ambulatory blood pressure,BPV indicators,Athens Insomnia Scale(AIS)scores of the two groups were observed.Moreover,the incidence of adverse reactions in the two groups during treatment was compared.Results(1)After treatment,the ambulatory blood pressure indicators such as 24-hour ambulatory systolic blood pressure(24hASBP),24-hour ambulatory diastolic blood pressure(24hADBP),and morning blood pressure surge(MBPS)in the two groups were decreased significantly when compared with those before treatment(P＜0.01),and the decrease in the observation group was significantly superior to that in the control group(P＜0.01).(2)After treatment,the BPV indicators such as 24-hour systolic standard deviation(24hSSD),24-hour diastolic standard deviation(24hDSD),daytime systolic standard deviation(dSSD),daytime diastolic standard deviation(dDSD),nighttime systolic standard deviation(nSSD),and nighttime diastolic standard deviation(nDSD)in the two groups were decreased when compared with those before treatment(P＜0.05 or P＜0.01),and the decrease of all of the BPV indicators in the observation group was significantly superior to that in the control group(P＜0.05 or P＜0.01).(3)The sleep quality of the patients in the two groups was significantly improved,and the AIS score and its grading were significantly improved when compared with those before treatment(P＜0.01),and the improvement in the observation group was significantly superior to that in the control group(P＜0.01).(4)During the treatment,no serious adverse reactions occurred in the two groups,and the incidence of adverse reactions in the observation group was 3.95%(3/76)and that in the control group was 11.84%(9/76),showing no statistically significant difference(P＞0.05).Conclusion The application of Pingtiao Granules on the basis of western medicine is effective on improving BPV in patients with hypertension complicated by sleep disorders of liver yang hyperactivity type,and can also reduce blood pressure level and morning blood pressure fluctuation and improve the quality of sleep of the patients,with high safety.
Pingtiao Granuleshypertensionsleep disordersliver yang hyperactivity typeambulatory blood pressureblood pressure variabilityretrospective study
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