Clinical Observation on Bushen Huoxue Lishui Prescription for the Treatment of Infertility Due to Hydrosalpinx
Objective To investigate the clinical efficacy of self-made Bushen Huoxue Lishui Prescription for the treatment of patients with infertility due to hydrosalpinx.Methods Seventy patients with infertility due to hydrosalpinx differentiated as spleen deficiency and phlegm blended with blood stasis type were randomly divided into the control group and the observation group,with 35 patients in each group.Patients in both groups were given minimally invasive surgery by using a combined hysteroscopy-laparoscopy approach,and additionally,the control group was given the postoperative routine treatment(including the use of antibiotics to prevent infections,regular monitoring of the basal body temperature,and the review of the uterine adnexa ultrasound),and the observation group was treated with Bushen Huoxue Lishui Prescription based on the treatment for the control group.The medication was performed for 21 days during a menstrual cycle,and the treatment lasted for three continuous menstrual cycle.Before and after treatment,the changes in the scores of the fallopian tube obstruction and scores of traditional Chinese medicine(TCM)syndrome in the two groups were observed.Three months after the operation,the pregnancy outcomes,the recurrence of hydrosalpinx in the non-pregnant patients,and the safety of the medication in the two groups were evaluated.Results(1)Three months after the operation,the total pregnancy rate of the observation group was 51.43%(18/35),and the intrauterine pregnancy rate was 48.57%(17/35);in the control group,the total pregnancy rate was 25.71%(9/35)and the intrauterine pregnancy rate was 20.00%(7/35).The intergroup comparison(by chi-square test)showed that the total pregnancy rate and intrauterine pregnancy rate of the observation group were significantly superior to those of the control group,and the differences were statistically significant(P＜0.05).(2)After treatment,the scores of the fallopian tube obstruction in the two groups were significantly improved when compared with those before treatment(P＜0.05),and the improvement of tubal obstruction scores in the observation group was significantly superior to that in the control group,with statistically significant differences in the post-treatment scores and in the pre-and post-treatment score difference between the two groups(P＜0.05).(3)After treatment,the TCM syndrome scores in the two groups were significantly improved when compared with those before treatment(P＜0.05),and the improvement of TCM syndrome score in the observation group was significantly superior to that in the control group,with statistically significant differences in the post-treatment scores and in the pre-and post-treatment score difference between the two groups(P＜0.01).(4)Three months after the operation,the recurrence rate of hydrosalpinx in the observation group was 5.88%(1/17),and lower than that in the control group(38.46%,10/26),with statistically significant differences(P＜0.05).(5)During the treatment,no obvious adverse reactions occurred in the two groups,and the safety was high.Conclusion Bushen Huoxue Lishui Prescription has markedly efficacy in the treatment of patients with infertility due to hydrosalpinx differentiated as spleen deficiency and phlegm blended with blood stasis type,and the prescription is effective on increasing the pregnancy rate of the patients,decreasing the recurrence of hydrosalpinx,and improving the clinical symptoms,with fewer adverse reactions and high safety.
Bushen Huoxue Lishui Prescriptioninfertility due to hydrosalpinxspleen deficiency and phlegm blended with blood stasis typeminimally invasive surgerypregnancy rate
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