摘要
乳腺癌是全球范围内女性健康的严重威胁.由于现阶段的放化疗方案可诱导癌组织出现抗凋亡、抗焦亡和抗坏死性凋亡等药物抵抗效应,使得乳腺癌的临床治疗效果不佳.铁死亡是一种新型程序性细胞死亡方式,以铁过载、活性氧大量生成和膜脂质过氧化为特征.铁死亡的发生是细胞内过氧化机制(执行系统)和抗氧化机制(防御系统)失衡的结果,具体包括铁代谢途径、氨基酸代谢途径和脂质代谢途径.近年来发现铁死亡与多种疾病的演进过程有关,如肿瘤、高血压、糖尿病和阿尔兹海默症等.研究证实,触发乳腺癌细胞铁死亡可显著抑制癌细胞增殖、侵袭,改善癌细胞对放化疗的敏感性等,这使得诱导铁死亡成为乳腺癌治疗的潜在策略.本文将对铁死亡的概念、特征及其在乳腺癌治疗中的研究进展作一综述,旨在为下一步的药物开发提供理论基础.
Abstract
Breast cancer is a critical threat to women around the globe.Current radio-and chemotherapy regimens can in-duce multiple drug-resistant effects,e.g.,anti-apoptosis,anti-pyroptosis,and anti-necroptosis,causing a poor clinical response to therapy.Ferroptosis is a newly programmed cell death characterized by iron overload,the massive production of reactive oxygen species,and membrane lipid peroxidation.The occurrence of ferroptosis results from an imbalance between peroxidation mecha-nisms(execution systems)and anti-oxidation mechanisms(defense systems),including the iron metabolism pathway,amino acid metabolism pathway,and lipid metabolism pathway.Recently,the vital role of ferroptosis in various diseases,including cancer,hypertension,diabetes,and Alzheimer's,has been identified.Specifically,triggering ferroptosis in breast cancer cells can inhibit their proliferation and invasion,and improve the chemoradiotherapy sensitivity,which makes it a potential strategy for breast can-cer therapy.This review summarizes the definition and features of ferroptosis,as well as its role in the treatment of breast cancer,aimed at providing a theoretical basis for future drug development.
国家科技期刊平台
NSTL
维普
万方数据