Advances in microRNA and inflammatory bowel disease and their related mechanisms
Inflammatory bowel disease(IBD)is a complex and multifactorial disease characterized by chronic inflamma-tion of the gastrointestinal tract,mainly manifested by the accumulation of immune cells and pro-inflammatory cytokines in the intestinal mucosa.It is a kind of immune digestive system disease with high incidence in humans,and can be divided into ulcer-ative colitis(UC)and Crohn's disease(CD).The pathogenesis of IBD is complex,and numerous studies have shown that ge-netic,environmental,microbial,immune,autophagy and other factors may be involved in the pathogenesis of IBD.microR-NAs(miRNAs)play an important role in the pathophysiology of IBD.Studies have confirmed that miRNA plays an important role in the targeted regulation of intestinal barrier homeostasis,immune response and intestinal epithelial autophagy.MiRNA have not only been confirmed as important diagnostic biomarkers for IBD.It also shows new prospects for treatment strategies for IBD.This article mainly describes the differences in miRNA expression between UC and CD,summarizes the relationship between miRNA and intestinal barrier,immune homeostasis and autophagy mechanism in the pathogenesis of IBD,and the re-search progress of miRNA involved in the diagnosis and treatment of IBD,so as to provide new insights for the development of IBD.
国家科技期刊平台
NSTL
万方数据
维普
