摘要
N6-甲基腺苷(N6-methyladenosine,m6A)是一种可逆的表观遗传修饰,是真核细胞中最丰富的修饰物之一,在信使RNA和非编码RNA中被普遍报道.m6A修饰可调节RNA的转录、加工、剪接、降解和翻译等,在肿瘤生物学行为中发挥重要作用.缺乏5'帽子结构的circRNA(circular RNA)一直被误认为是转录过程中偶然剪切生成的"垃圾序列",然而研究发现,circRNA可以通过microRNA、结合蛋白、翻译多肽和m6A修饰等多种方式参与肿瘤侵袭和转移.本文就m6A修饰在circRNA调控作用及其在肝细胞癌中的功能作一综述,并讨论其在该领域的潜在临床应用和可能的未来发展方向.
Abstract
N6-methyladenosine(m6A)is a reversible epigenetic modification,which is one of the most abundant modifi-ers in eukaryotic cells,and has been commonly reported in messenger RNAs and non-coding RNAs.The processing modification of m6A regulates RNA transcription,processing,splicing,degradation,and translation,and plays an important role in the biologi-cal process of tumors.Circular RNA,which lacks the 5'cap structure,has been mistakenly regarded as a"junk sequence"generat-ed by accidental shearing during the transcription process.However,it has been found that circRNAs can be involved in tumor in-vasion and metastasis through microRNAs,binding proteins,translated peptides,and m6A modifications.In this paper,we re-viewed the role of m6A modifications in circRNA regulation and their functions in hepatocellular carcinoma,and discussed their po-tential clinical applications and future development in this field.
基金项目
海南省重点项目研发计划(ZDYF2020134)
海南省重点项目研发计划(ZDYF2022SHFZ283)
海南省自然科学基金(821QN391)
国家科技期刊平台
NSTL
维普
万方数据