Alzheimer's disease(AD)is an irreversible neurodegenerative disease with a variety of pathogenic factors and com-plex pathogenesis,so that the disease has a high prevalence and mortality in the world.Although the current diagnosis and treat-ment equipment and drug research and development keep pace with the times,the current medical technology still can not com-pletely cure the disease,so it is of great significance to explore the pathogenesis and treatment target of AD.The disorder of ener-gy metabolism is one of the characteristic changes in the pathological process of AD.Aerobic glycolysis(AEG)is a special meta-bolic pathway in the brain,which can rapidly consume glucose to produce energy and substrate for neurons,improve synaptic plas-ticity,neuroinflammation and oxidative damage,and contribute to the recovery of memory and cognitive function.In recent years,many literatures have reported the mechanism of AEG in AD and the intervention of traditional Chinese medicine on this mecha-nism.The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by traditional Chinese medicine,in order to provide reference and ideas for the prevention and treat-ment of AD with traditional Chinese medicine in the future.
关键词
阿尔茨海默病/有氧糖酵解/中医药/能量代谢
Key words
Alzheimer disease/Aerobic glycolysis/Traditional Chinese medicine/Energy metabolism
维普
万方数据