Exploration of standard dosage for GnRH antagonist protocol and dosage adjustments after premature luteinizing hormone surge
The gonadotropin-releasing hormone(GnRH)antagonist protocol has emerged as an efficacious alternative to the GnRH agonist protocol for controlled ovarian hyperstimulation(COH)during in vitro fertilization(IVF)cycles,and has been demonstrated applicability in infertile female patients with diverse ovarian responses.While the clinical implementation of the antag-onist COH protocol has achieved widespread consensus,opportunities for refinement persist.Therefore,this review article focus-es on the advantages and disadvantages of GnRH antagonist protocol,the selection of optimal standard doses,and the strategies for adjusting antagonist doses after the premature luteinizing hormone(LH)surge,aiming to provide more reasonable and scientif-ic recommendations for the application of this scheme.
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