Sequential experimental observation on the curative effect of Yingbupu decoction of Zhuang medicine on stage Ⅰ and Ⅱ acute kidney injury
Objective:To observe the clinical efficacy of Yingbupu decoction of Zhuang medicine on stage Ⅰ and Ⅱ acute kidney injury(AKI)through sequential test.Methods:The open one-way qualitative response sequential design of experiments was adopted,and the patients with AKI in phase Ⅰ and Ⅱ who met the inclusion criteria were divided into the treatment group and the control group according to the order of hospitalization by random number table.On the basis of basic treatment,the treat-ment group was treated with Yingbupu decoction of Zhuang medicine,and the control group was treated with Jinshuibao tablet.The clinical efficacy,TCM syndrome score,24-hour urine volume,serum creatinine(Scr),microalbumin in urine(mAlb),neu-trophil Gelatinase related lipid delivery albumin(NGAL)of the two groups were compared,and the adverse reactions and compli-cations of the two groups were observed.Results:After 14 days of treatment,when the 10th case of treatment group was ob-served,the experimental line contacted the upper bound U-line and reached the experimental standard to terminate the experiment.The effective hypothesis was accepted,and it was believed that the Yingbupu decoction of Zhuang medicine had a therapeutic ef-fect on stage Ⅰ and Ⅱ of AKI.The conclusion was drawn that the treatment group received the Zhuang medicine Yingbupu.The clinical effective rate and improvement days were similar between the two groups,and there was no significant difference(P>0.05).However,the integral value of traditional Chinese medicine syndrome in the treatment group was lower than that in the con-trol group(P<0.05),After treatment,the Scr,mAlb,and NGAL levels of patients in both groups were lower than those before treatment(P<0.05).After treatment,the Scr,mAlb,and NGAL values in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the 24-hour urine volume in both groups was higher than that before treat-ment,and the values in the treatment group were significantly higher than those in the control group(P<0.05).During the treat-ment period,there were no significant adverse reactions or complications in either group.Conclusion:The Yingbupu decoction of Zhuang medicine is effective in treating stage Ⅰ and Ⅱ of AKI,and the Yingbupu decoction of Zhuang medicine can significantly improve the symptoms and quality of life of patients with stage Ⅰ and Ⅱ of AKI.Its improvement of renal function is better than that of Jinshuibao tablets with high safety.
Zhuang medicine Yingbupu decoctionAcute kidney injurySequential test
周雁、黄国东、谢璋庆、周嫦艳、梁静妍、罗佳
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广西中医药大学,广西 南宁 530000
广西国际壮医医院,广西 南宁 530000
南宁市中医医院,广西 南宁 530000
壮药鹰不扑 急性肾损伤 序贯试验
2021 Guangxi Famous Traditional Chinese Medicine Inheritance Studio Construction Project2021年广西名中医传承工作室建设项目人才培养重点学科-民族医学(壮医学)广西中医药大学2021年研究生创新创业项目
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