Meta-analysis of the efficacy and safety of Bushen Huoxue decoction in the treatment of Osteoporosis
Objective:To systematically evaluate the long-term efficacy of Bushen Huoxue decoction combined with verte-broplasty(PVP or PKP)in the treatment of osteoporotic vertebral compression fractures(OVCF),in order to provide evidence-based reference for clinical application.Methods:To ensure the novelty and reliability of research data,all randomized controlled studies and clinical trials publishd between January 2017 and February 2023 at home and abroad on the treatment of OVCF with Bushen Huoxue Decoction combined with vertebroplasty in CNKI,Wanfang,Vip,PubMed,CBM,and Cochrane libraries were searched.Two researchers independently conducted literature screening and data extraction,evaluated the quality of randomized controlled trials one by one according to the Cochrane collaboration network standards,and conducted a meta statistical analysis us-ing RevMan5.3 for studies that met the inclusion criteria.Results:A total of 684 patients were included in seven randomized con-trolled trials,including 342 patients in the observation group and 342 patients in the control group,with a ratio of 1:1;The meta-analysis results showed that in the observation group,the overall effective rate[RR=1.30,95%CI(1.14,1.47),P<0.000 1],visual analog pain(VAS)score[SMD=1.19,95%CI(0.77,1.61),P<0.000 01],bone mineral density score[SMD=1.09,95%CI(0.15,2.04),P=0.02],COQOL score[SMD=0.99,95%CI(0.68,1.30),P<0.000 01],OPG score[SMD=0.48,95%CI(0.18,0.77),P=0.002]and the RANKL score[SMD=1.33,95%CI(1.00,1.65),P<0.000 01]were significantly su-perior to the control group,with statistically significant differences.There was no significant difference in the Oswestry Disability Index(ODI)score[SMD=0.27,95%CI(-0.03,0.57),P=0.08],Cobb score[SMD=1.52,95%CI(-1.05,4.09),P= 0.25],and vertebral height score[SMD=0.43,95%CI(-0.14,1.01),P=0.14].Conclusion:The results show that Bushen Huoxue decoction combined with vertebroplasty has significant advantages in improving bone mineral density and alleviating pain in patients after OVCF,which is significantly superior to using OVCF alone.
国家科技期刊平台
NSTL
万方数据
维普
