In recent years,with the development of medical technology,the detection rate of cancer is getting higher and higher,and the population of patients is getting younger.Many studies have begun to study the early diagnosis,prognostic moni-toring markers and pathogenesis of cancer.In recent years,with the development of bioinformatics technology,lncRNA have grad-ually attracted the attention of researchers.More and more studies have shown that lncRNA are responsible for various biological functions in the process of cancer progression.lncRNA MAFG-AS1 has been shown to be associated with multiple cancers,func-tion as an oncogene,and is significantly associated with poor clinical features and prognosis.This article reviews the research prog-ress of lncRNA MAFG-AS1 in cancer,hoping to provide some help for the future clinical diagnosis and treatment of cancer.