Recent research progress from biological perspective on the mechanism of formation of osteoarthritis after anterior cruciate ligament injury
The anterior cruciate ligament(ACL)mainly plays a role in stabilizing the knee joint by limiting the forward translation of tibial force and rotational force at the tibial joint,and if this ligament is damaged,it will cause joint pain,limited mo-bility,and knee instability etc.According to related studies,the incidence of post-traumatic osteoarthritis(PTOA)after ACL inju-ry is as high as 87%,although many studies have shown that patients with ACL injury are susceptible to PTOA,but the exact mechanism is currently unknown.This may be related to biological,structural,and mechanical factors caused by the ligament inju-ry.Previous studies have shown that elevated inflammatory mediators in the joint cavity following ACL injury can lead to chondro-cytes necrosis and degradation of the cartilage matrix.These potential biochemical mediators contribute to PTOA formation,and early intervention can reduce future episodes of PTOA.In recent years,many scholars have devoted themselves to studying the po-tential important factors and signaling pathways involved in the formation of osteoarthritis after ACL injury,and exploring its mo-lecular mechanism,which has led to great progress in this field.This paper mainly studies and discusses the mechanism of osteoar-thritis formation after ACL injury from the biological perspective.
国家科技期刊平台
NSTL
万方数据
维普
