Association of ABCG2,PDZK1,SLC22A12 gene polymorphisms with hyperuricemia in the males of Han ethnic group in Urumqi
Objective:To investigate the association between rs2231142 locus of ABCG2 gene,rs12129861 locus of PDZK1 gene and rs505802 locus of SLC22A12 gene and hyperuricemia in the males of Han ethnic group in Urumqi.Methods:A total of 334 males of Han ethnic group with hyperuricemia who visited the First Affiliated Hospital of Xinjiang Medical University were selected as the hyperuricemia group,and 488 healthy males of Han ethnic group from the same hospital were selected as the control group.Peripheral venous blood samples were obtained to biochemical indicators.Genetic testing was performed using mul-tiple ligase detection reactions,and the association between different genotypes of ABCG2,PDZK1,SLC22A12 and hyperurice-mia was analyzed.Results:The blood urea nitrogen,creatinine,triglyceride,high density lipoprotein(HDL),low density lipo-protein(LDL),diastolic blood pressure and the BMI of both groups were significantly higher than that of the control group(P<0.05);no notable disparities were observed in terms of age.There were no appreciable variations in blood glucose and systolic blood pressure between the two groups(P>0.05).Following adjusting for age,regular exercise and other confounding factors,multivariate unconditional logistic regression analysis showed that the rs12129861 and rs2231142 genotypes in the Urumqi Han population with hyperuricemia were significantly different from the control group(P<0.05).Individuals with the GT+TT geno-type of ABCG2 gene were observed to have a 1.767 times increased risk of hyperuricemia compared to the control group(95%CI:1.332,2.343,P<0.05).Individuals with the GA+AA genotype of the PDZK1 gene were found to have a 0.649 times greater risk of hyperuricemia compared to the control group(95%CI:0.484,0.810,P<0.05).Interaction analysis revealed an association be-tween these three loci interactions and the development of hyperuricemia(P<0.05).There was no significant association between rs505802 genotype and hyperuricemia(P<0.05).Conclusion:The rs2231142 locus of ABCG2 gene and rs12129861 locus of PDZK1 gene are the main risk factors for hyperuricemia in Urumqi Han male population(P<0.05).Allele T may be a risk factor for hyperuricemia,while allele A may be a protective factor.
国家科技期刊平台
NSTL
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