The influence of autophagy on liver fibrosis and the progress of TCM treatment
Autophagy is an important process of cell growth,survival and homeostasis.The disorder of autophagy is in-volved in the occurrence and development of many diseases.According to the pathway by which the degradation components caused by autophagy reach the lysosomes,autophagy can be divided into macroautophagy,microautophagy and chaperon-mediated autophagy.Among them,macroautophagy is a more widely studied form of cellular autophagy,which plays an important role in the occurrence and development of liver fibrosis.The role of autophagy in liver fibrosis depends on the type of cells and the stage of the disease,so regulation of autophagy may provide a new therapeutic strategy for reversing liver fibrosis.De-cades of research has proved that traditional Chinese medicine has outstanding effects in the treatment of liver fibrosis and can im-prove the reversal rate of liver fibrosis.In recent years,many Chinese herbal compounds have been reported to regulate autophagy and improve liver fibrosis.It is important to clarify the significance of autophagy on liver fibrosis and the understanding of TCM the-ory on autophagy and liver fibrosis.This article mainly discusses the influence of autophagy on liver fibrosis and the progress of Chi-nese medicine regulation of autophagy on anti-liver fibrosis treatment.
AutophagyLiver fibrosisMolecular mechanismCorrelation pathTraditional Chinese medicineProgress
万方数据
维普
